Actively Recruiting
Impact of Aorto-Iliac Occlusive Disease Treatment on Blood Pressure
Led by Rijnstate Hospital · Updated on 2026-04-03
20
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hypertension is a major risk factor for a variety of cardiovascular diseases. When hypertension results from increased vascular resistance due to a narrowing of the descending aorta, it can be effectively treated with stenting. More recently, evidence suggest that stenting in more distal parts of the arterial vascular bed is also associated with a reduction in blood pressure. The investigators hypothesize that stenting of occlusions more distal of the descending aorta decreases the central blood pressure and afterload as reflected by NT-proBNP (N-terminal pro-Brain Natriuretic Peptide), a biomarker of intracardiac pressures and predictor of heart failure events. The goal of this pilot study is to prospectively investigate changes in blood pressure after stent placement in the aorto-iliac region.
CONDITIONS
Official Title
Impact of Aorto-Iliac Occlusive Disease Treatment on Blood Pressure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �38 years
- Signed informed consent
- Chronic occlusion in the infrarenal aorta and/or one or both common iliac arteries
- Total lesion length of �30mm or more
- Clinical indication for treatment such as chronic limb threatening ischemia or disabling intermittent claudication not responding to supervised exercise training
You will not qualify if you...
- Unable to understand study requirements or unwilling to adhere to follow-up
- Juxtarenal pathology less than 2 cm below the lowest renal artery
- Acute occlusion of the target area (Acute Leriche Syndrome)
- Embolic disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rijnstate
Arnhem, Netherlands, 6815AD
Actively Recruiting
Research Team
M
Michel Reijnen, prof.dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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