Feasibility Study of a Smartphone-Based HIV-Specific Smoking Cessation Program Combined With Lung Cancer Screening in People Living With HIV Ages 45 to 80

What this Trial Is About

Researchers are evaluating a smartphone-based, HIV-specific behavioral smoking cessation program called Positively Smoke Free - Mobile in people living with HIV PLWH who smoke. The study aims to assess the feasibility of delivering this intervention alongside low dose non-contrast lung CT scans LDCT to help patients quit smoking and to monitor adherence to lung cancer screening in this population. Secondary goals include measuring smoking cessation rates, nicotine replacement use, and lung screening outcomes such as lung cancer and other findings. Participants will use the Positively Smoke Free - Mobile app for 42 days and receive nicotine replacement therapy for 12 weeks. Within 60 days of enrolling, they will undergo a low dose chest CT scan for lung cancer screening. After completing the intervention, participants will be followed up at 3, 6, and 12 months to assess smoking status, screening results, and patient-reported outcomes like anxiety, insomnia, and pain. During the study, researchers will track how well participants engage with the app and complete the lung CT scan within the specified timeframe. Smoking cessation will be measured at 3 and 6 months, along with nicotine replacement use. Safety and tolerability of lung screening will be evaluated through patient questionnaires on symptoms such as anxiety and concentration problems. The study lasts up to one year after intervention completion, providing ongoing monitoring of lung health and smoking behavior.

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study