Actively Recruiting
Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR)
Led by University Hospital, Basel, Switzerland · Updated on 2025-11-28
498
Participants Needed
11
Research Sites
199 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multi-centric, open-label, randomized trial to evaluate the safety and efficacy of temporary discontinuation of beta-blocker treatment in patients undergoing transcatheter aortic valve replacement.
CONDITIONS
Official Title
Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent before any study intervention
- Adults over 18 years old with severe symptomatic aortic stenosis
- Scheduled for elective transcatheter aortic valve replacement (TAVR)
- Currently on beta-blocker therapy for at least one month before joining the study
You will not qualify if you...
- Emergency or urgent need for TAVR
- Unstable heart condition requiring inotropic medication
- Already have a permanent pacemaker
- Need for pacemaker implantation
- Significant left ventricular outflow tract obstruction
- Previous intolerance to beta-blockers
- Life expectancy less than one year
- Known or suspected drug or alcohol abuse
- Unable to give consent or follow study procedures due to language, psychological, or cognitive issues
- Dependent relationship with trial site
- Participation in another investigational drug study within 30 days before or during this study
- Previously enrolled in this study
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 11 locations
1
Medical University of Graz
Graz, Austria, 8036
Actively Recruiting
2
University Hospital Salzburg
Salzburg, Austria, 5020
Actively Recruiting
3
University Medical Center Freiburg
Bad Krozingen, Germany, 79189
Actively Recruiting
4
Kerckhoff-Klinik GmbH
Bad Nauheim, Germany, 61231
Actively Recruiting
5
Herz- und Diabeteszentrum NRW Universitätsklinik
Bad Oeynhausen, Germany, 32545
Actively Recruiting
6
Universitätsklinikum Giessen und Marburg GmbH
Giessen, Germany, 35392
Actively Recruiting
7
Universitätsklinikum Schleswig-Holstein AöR
Kiel, Germany, 24105
Actively Recruiting
8
University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
9
Inselspital, Bern University Hospital
Bern, Switzerland, 3010
Actively Recruiting
10
Geneva University Hospitals
Geneva, Switzerland, 1205
Actively Recruiting
11
University Hospital of Zürich
Zurich, Switzerland, 8091
Actively Recruiting
Research Team
N
Nicole Gilgen, Dr. med.
CONTACT
T
Thomas Nestelberger, PD Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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