Effect of Beta-Glucan Supplementation with a Low-Calorie, Low-Carbohydrate Diet on Body Weight, Fat Loss, Appetite, and Hormones in Healthy Overweight Women

What this Trial Is About

This research aims to evaluate whether adding beta-glucan supplements to a calorie- and carbohydrate-restricted diet helps women with overweight or obesity lose body weight and fat, while also reducing negative changes in appetite and related hormones. The trial is a double-blind, randomized, controlled study involving healthy females aged 18 to 60 with a BMI between 25 and 39.9. It compares beta-glucan to a placebo cellulose to understand its effects during dietary restriction. Participants will be randomly assigned to one of two groups one receiving 9 grams per day of beta-glucan and the other receiving 9 grams per day of cellulose as a placebo. Both groups will follow a 4-week diet with low-calorie liquid meal replacements for breakfast and dinner, each providing 200 kcal, and low-carbohydrate lunches making up 35% of habitual energy intake. Supplements are taken with each main meal, and participants receive support and monitoring during the intervention. Before and after the 4-week intervention, participants undergo experimental trials involving fasting body weight and composition measurements, saliva collection to assess body water, and blood sampling over 4 hours to measure appetite hormones. Subjective appetite is recorded using questionnaires. Participants also track their food and drink intake for three days before each trial day. The study measures body weight, total body water, subjective appetite, and gastrointestinal appetite hormones to assess the interventions impact.

Impact of Beta-glucan Supplementation During Calorie and Carbohydrate-restricted Diet on Body Weight and Body Fat Loss, Appetite, and Gastrointestinal Appetite Hormones.