Initial validation of a virtual blood draw exposure paradigm for fear of blood and needles.
Z Trost, A Jones, A Guck...
https://pubmed.ncbi.nlm.nih.gov/28780134Actively Recruiting
Phase Not Applicable
Age: 18Years - 50Years
All Genders
Healthy Volunteers
ID06336031
Impact of Blood Phobia on Fainting Susceptibility: A Randomized Study of Cardiovascular Responses to Emotional Stimuli During Upright Tilt Testing
Led by Simon Fraser University · Updated on 2025-05-15
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how the body's cardiovascular autonomic system responds to emotional triggers, specifically blood-injection-injury (needle) phobia, during an upright posture challenge. This study compares individuals with and without needle phobia to better understand why some people have low blood pressure reactions that can lead to fainting. Such reactions are common in medical settings and can cause avoidance of important health care, which impacts public health and healthcare systems. Participants will undergo a "tilt test" on two separate days in a randomized order. On one day, they will view images and videos related to blood-injection-injury phobia, and on the other day, they will see neutral content. Each exposure lasts about 498 seconds and begins two minutes before the upright tilt test. Cardiovascular responses will be closely monitored throughout the tests. During the study, volunteers will be assessed for cardiovascular control and tolerance to standing upright, measured by the time until near fainting occurs. Researchers will record heart and blood pressure changes while participants watch the videos and images. The main outcome is orthostatic tolerance, observed over a period of up to 50 minutes. The study aims to provide detailed insights into fainting susceptibility related to needle phobia and will run until December 2026.
CONDITIONS
Brief Title
Impact of Blood Phobia on Fainting Susceptibility
Who Can Participate
Age: 18Years - 50Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Male and female adults aged 18 to 50 years
- Individuals with or without suspected blood-injection-injury phobia
- English speaking
You will not qualify if you...
- Diagnosis of any cardiovascular or neurological disorder
- Menopausal status
- Taking medication for a cardiovascular condition
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Intervention Testing Days
Duration - 2 separate days
Participants undergo two separate test days where they watch either blood-injection-injury phobia stimuli or neutral stimuli during an upright tilt test to assess cardiovascular responses and orthostatic tolerance.
2 visits (in-person)
Trial Site Locations
Total: 1 location
1
Simon Fraser University
Burnaby, British Columbia, Canada, V5A 1S6
Actively Recruiting
Loading map...
Research Team
V
Victoria E Claydon, PhD
V
Vera E Lucci, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
The epidemiology of DSM-IV specific phobia in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
Frederick S Stinson, Deborah A Dawson, S Patricia Chou...
https://pubmed.ncbi.nlm.nih.gov/17335637How afraid are you of having blood drawn from your arm? A simple fear question predicts vasovagal reactions without causing them among high school donors.
Christopher R France, Janis L France, Lina K Himawan...
https://pubmed.ncbi.nlm.nih.gov/22670781Forearm vascular responses during orthostatic stress in control subjects and patients with posturally related syncope.
C M Brown, R Hainsworth
https://pubmed.ncbi.nlm.nih.gov/10823336Vascular responses to orthostatic stress in patients with postural tachycardia syndrome (POTS), in patients with low orthostatic tolerance, and in asymptomatic controls.
V E Bush, V L Wight, C M Brown...
https://pubmed.ncbi.nlm.nih.gov/11198483Salt supplementation improves orthostatic cerebral and peripheral vascular control in patients with syncope.
Victoria E Claydon, Roger Hainsworth
https://pubmed.ncbi.nlm.nih.gov/14981050Cerebral autoregulation during orthostatic stress in healthy controls and in patients with posturally related syncope.
Victoria E Claydon, Roger Hainsworth
https://pubmed.ncbi.nlm.nih.gov/14564654Combined head-up tilt and lower body suction: a test of orthostatic tolerance.
K M el-Bedawi, R Hainsworth
https://pubmed.ncbi.nlm.nih.gov/8054836Carotid baroreceptor reflexes in humans during orthostatic stress.
V L Cooper, R Hainsworth
https://pubmed.ncbi.nlm.nih.gov/11571497Effects of dietary salt on orthostatic tolerance, blood pressure and baroreceptor sensitivity in patients with syncope.
Victoria Louise Cooper, Roger Hainsworth
https://pubmed.ncbi.nlm.nih.gov/12357276