Effects of Balloon Pulmonary Angioplasty on Heart and Lung Function in CTEPH Patients Assessed by Advanced Cardiovascular MRI 4D Flow

What this Trial Is About

Researchers are investigating the impact of Balloon Pulmonary Angioplasty BPA on cardiac and pulmonary physiology in patients with Chronic Thromboembolic Pulmonary Hypertension CTEPH. The study focuses on evaluating changes in cardio-pulmonary vascular physiology using advanced Cardiovascular Magnetic Resonance CMR 4D flow haemodynamics. Patients referred for BPA will undergo comprehensive standard diagnostic tests including echocardiography, right heart catheterization RHC, and coronary artery disease assessments through both invasive and non-invasive methods. Participants will receive BPA typically across 5 to 6 consecutive treatment sessions. CMR imaging will be performed before the first BPA session and again after the last intervention to assess treatment effects. The patient recruitment period is planned to last three years, with the last BPA session for the final patient occurring within this timeframe. During the study, patients will undergo standard diagnostic evaluations and CMR scans to monitor heart and lung function changes. Researchers will measure the impact of BPA on cardio-pulmonary vascular physiology over a one-year period. The study involves follow-up CMR assessments to track physiological changes and support understanding of treatment outcomes in CTEPH patients.

Impact of BPA in CTEPH on Cardiac and Pulmonary Physiology Assessed by CMR-derived 4D Flow Haemodynamics