Actively Recruiting
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
Led by Dennis M. McNamara, MD, MS · Updated on 2025-09-22
250
Participants Needed
64
Research Sites
335 weeks
Total Duration
On this page
Sponsors
D
Dennis M. McNamara, MD, MS
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study will enroll 200 women newly diagnosed with peripartum cardiomyopathy within 5 months postpartum in a randomized placebo controlled trial of bromocriptine therapy to evaluate its impact on myocardial recovery and clinical outcomes. Given that bromocriptine prevents breastfeeding, an additional 50 women with peripartum cardiomyopathy excluded from the trial due to a desire to continue breastfeeding but meeting all other entry criteria will be followed in an observational cohort.
CONDITIONS
Official Title
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- New diagnosis of peripartum cardiomyopathy
- Within 5 months postpartum
- LVEF of 0.40 or less within 4 weeks before consent for randomized trial
- LVEF of 0.40 or less within 8 weeks before consent for breastfeeding cohort
- Age 18 years or older
You will not qualify if you...
- Previous cardiomyopathy, valvular disease or congenital heart disease (except women with prior peripartum cardiomyopathy fully recovered with LVEF > 0.55 before or early in pregnancy)
- Uncontrolled high blood pressure (systolic >160 or diastolic >95) at enrollment or qualifying LVEF
- Currently breastfeeding and planning to continue
- Evidence of significant coronary artery disease (>50% stenosis or positive stress test)
- Previous heart transplant
- Current durable left ventricular assist device (LVAD) support
- Need for extracorporeal membrane oxygenation (ECMO)
- Current alcohol or drug abuse
- Chemotherapy or chest radiation within past 5 years
- Ongoing bacterial septicemia
- Medical, social, or psychiatric issues limiting study follow-up compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 64 locations
1
University of Alabama Birmingham
Birmingham, Alabama, United States, 35205
Actively Recruiting
2
University of Arizona Sarver Heart Center
Tucson, Arizona, United States, 85724
Actively Recruiting
3
University of California San Diego
La Jolla, California, United States, 92037-7411
Actively Recruiting
4
Keck School of Medicine of USC
Los Angeles, California, United States, 90033
Actively Recruiting
5
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
6
University of California Irvine Health
Orange, California, United States, 92868
Actively Recruiting
7
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
8
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
9
Hartford Hospital
Hartford, Connecticut, United States, 06106
Actively Recruiting
10
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
11
University of Florida
Gainesville, Florida, United States, 32608
Actively Recruiting
12
Mayo Clinic, Florida
Jacksonville, Florida, United States, 32216
Actively Recruiting
13
University of South Florida
Tampa, Florida, United States, 33606
Actively Recruiting
14
Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
15
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
16
University of Illinois Health Heart Center
Chicago, Illinois, United States, 60612
Actively Recruiting
17
Indiana University/Indiana University Health
Indianapolis, Indiana, United States, 46202
Actively Recruiting
18
Ascension St. Vincent Heart Center
Indianapolis, Indiana, United States, 46260
Actively Recruiting
19
University of Iowa Hospitals and Clinic
Iowa City, Iowa, United States, 52242
Actively Recruiting
20
University of Kentucky, Gill Heart & Vascular Institute
Lexington, Kentucky, United States, 40536
Actively Recruiting
21
Louisiana State University
Shreveport, Louisiana, United States, 71103
Actively Recruiting
22
University of Maryland Medical Center, Baltimore
Baltimore, Maryland, United States, 21201
Actively Recruiting
23
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
24
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
25
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
26
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
27
Henry Ford Health System
Detroit, Michigan, United States, 48202
Actively Recruiting
28
Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
29
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
30
Mayo Clinic, Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
31
Karen L Florio, MD
Columbia, Missouri, United States, 65201
Actively Recruiting
32
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, United States, 64154
Actively Recruiting
33
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
34
NYU Langone Health
New York, New York, United States, 10022
Actively Recruiting
35
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
36
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
37
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
38
Stony Brook Medicine
Stony Brook, New York, United States, 11794
Actively Recruiting
39
Albert Einstein College of Medicine/ Montefiore Medical Center
The Bronx, New York, United States, 10461
Actively Recruiting
40
Atrium Health Sanger Heart and Vascular Institute
Charlotte, North Carolina, United States, 28204
Actively Recruiting
41
University Hospitals, Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
42
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
43
Oklahoma university Health Science Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
44
Lehigh Valley Health Network
Allentown, Pennsylvania, United States, 18105
Withdrawn
45
Penn State Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
46
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
47
Temple Heart and Vascular Institute
Philadelphia, Pennsylvania, United States, 19140
Actively Recruiting
48
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15237
Actively Recruiting
49
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
Actively Recruiting
50
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
51
Stern Cardiovascular Foundation, Inc
Germantown, Tennessee, United States, 38138
Actively Recruiting
52
Vanderbilt
Nashville, Tennessee, United States, 37232
Actively Recruiting
53
UT Southern Medical Center
Dallas, Texas, United States, 75390-8830
Withdrawn
54
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
55
University of Texas Health San Antonio
San Antonio, Texas, United States, 78229
Withdrawn
56
Intermountain Medical Center
Murray, Utah, United States, 84107
Actively Recruiting
57
University of Vermont Medical Center
Burlington, Vermont, United States, 05401
Actively Recruiting
58
University of Virginia
Charlottesville, Virginia, United States, 22908
Actively Recruiting
59
Inova Healthcare Services
Fairfax, Virginia, United States, 22031
Actively Recruiting
60
Old Dominion University
Norfolk, Virginia, United States, 23507
Actively Recruiting
61
Virginia Commonwealth University
Richmond, Virginia, United States, 23298
Actively Recruiting
62
University of Washington Medical Center
Seattle, Washington, United States, 98195
Actively Recruiting
63
University of Wisconsin Madison
Madison, Wisconsin, United States, 53792
Actively Recruiting
64
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
D
Dennis McNamara, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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