Actively Recruiting
Led by Aristotle University Of Thessaloniki · Updated on 2025-12-19
100
Participants Needed
1
Research Sites
8 weeks
Total Duration
Researchers are studying the effects of intravenous beta-blockers on the size of the damaged heart area after a heart attack called ST-elevation myocardial infarction (STEMI). The study aims to find out if giving landiolol, a specific beta-blocker, early after the heart attack can reduce the damage compared to standard oral beta-blockers. This is an observational study enrolling patients undergoing primary angioplasty for STEMI, where treatment choice depends on the cardiologist's judgment without random assignment. Patients will be grouped based on whether they receive intravenous landiolol or oral beta-blockers according to current European Society of Cardiology guidelines. The size of the heart damage will be measured by cardiac magnetic resonance imaging at least three months after the heart attack. Heart function will also be checked during hospital stay using echocardiography, including a specific measurement called global longitudinal strain. Blood tests and continuous heart rhythm monitoring will be done to assess injury markers and arrhythmia during hospitalization. Participants will undergo cardiac imaging, heart function tests, and blood sampling at scheduled times during and after hospital care. Researchers will track heart rhythm over the first 24 hours and monitor safety outcomes like shock, slow heart rate, low blood pressure, and heart failure during hospital stay up to 10 days. The main outcomes include infarct size measured by MRI after three months and heart function early after the heart attack. The total study period involves initial hospitalization and follow-up imaging months later.
CONDITIONS
Impact of Cardio-Selective Beta-Blockers on Infarct Size After Acute Myocardial Infarction
You may qualify if you...
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 days
Participants are monitored from admission through hospital discharge to assess heart function, arrhythmia burden, and safety outcomes.
Daily assessments during hospital stay
Duration - Within first 5 days and up to 3 months after myocardial infarction
Participants undergo imaging and biomarker assessments to evaluate heart injury and function after myocardial infarction.
Multiple visits including imaging at least 3 months after infarction
Total: 1 location
1
Hippokration General Hospital of Thessaloniki
Thessaloniki, Thessaloniki, Greece, 546 42
Actively Recruiting
A
Athina Nasoufidou, MD, MSc, PhDc
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Athina Nasoufidou, Marios G Bantidos, Panagiotis Stachteas...
https://pubmed.ncbi.nlm.nih.gov/40806838