Post-operative ileus: definitions, mechanisms and controversies.
Cameron I Wells, Tony G E Milne, Sean Ho Beom Seo...
https://pubmed.ncbi.nlm.nih.gov/34676664Actively Recruiting
Phase Not Applicable
Age: 17Years - 85Years
All Genders
ID07425249
Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery Patients A Randomized Controlled Trial at Khyber Teaching Hospital, Peshawar, Pakistan
Led by Khyber Medical University Peshawar · Updated on 2026-02-20
96
Participants Needed
1
Research Sites
9 weeks
Total Duration
On this page
Sponsors
K
Khyber Medical University Peshawar
Lead Sponsor
K
Khyber Teaching Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the effect of chewing gum on the early recovery of gastrointestinal movement in patients undergoing open gastrointestinal surgery. The study focuses on postoperative ileus, a common complication after abdominal surgery that causes delayed bowel function, longer hospital stays, and increased discomfort. This randomized controlled trial aims to determine whether chewing gum can speed up the return of normal gut activity after surgery. Participants are randomly assigned to one of two groups. The intervention group will chew glucose-containing chewing gum starting six hours after surgery for 15 minutes, three times a day, for up to 48 hours or until they pass gas or stool. The control group will receive standard postoperative care without chewing gum. Both groups will be monitored to compare the recovery of bowel function. During the study, researchers will track the time it takes for participants to first hear bowel sounds and for them to pass gas and have a bowel movement within 48 hours after surgery. Participants will receive regular postoperative care, and their recovery will be carefully observed to assess how chewing gum influences gut motility. The study will follow participants from the time of surgery through the first two days of recovery.
CONDITIONS
Brief Title
Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery Patients
Who Can Participate
Age: 17Years - 85Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age between 17 and 85 years.
- Patients of either gender.
- Undergoing open gastrointestinal surgical procedures (elective or emergency).
- Willing to participate and able to provide informed consent.
You will not qualify if you...
- Patients with metabolic or endocrine disorders such as diabetes mellitus, hypothyroidism, or hyperthyroidism.
- Patients with renal disease or electrolyte imbalance.
- Patients with chronic constipation or neuromuscular disorders.
- Patients with substance abuse or drug addiction.
- Patients receiving medications affecting gut motility such as calcium channel blockers or antiepileptic drugs.
- Patients with dental prosthesis or undergoing laparoscopic gastrointestinal surgery.
AI-Screening
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Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery and Immediate Post-operative Care
Duration - Day of surgery and following 48 hours
Participants undergo open gastrointestinal surgery followed by immediate post-operative care.
Hospital stay visits during initial 48 hours post-surgery
Inpatient Treatment
Duration - Up to 48 hours postoperatively
Participants in the intervention group chew glucose-containing chewing gum for 15 minutes, three times daily, starting 6 hours after surgery and continuing for up to 48 hours or until first passage of flatus or stool, in addition to standard postoperative care. Control group participants receive standard postoperative care without chewing gum.
Multiple chewing gum sessions 3 times daily during hospital stay
Post-operative Follow-up
Duration - Up to 48 hours postoperatively
Participants are monitored for return of bowel function including time to first bowel sounds, passage of flatus, and defecation.
Continuous monitoring during hospital stay
Trial Site Locations
Total: 1 location
1
Khyber Teaching Hospital
Peshawar, KPK, Pakistan, 25000
Actively Recruiting
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Research Team
D
Dr Ali Raza, MBBS
D
Dr Munir Ahmed, FCPS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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Published Research Related To This Trial
Effect of chewing gum on the postoperative recovery of gastrointestinal function.
Wei Ge, Gang Chen, Yi-Tao Ding
https://pubmed.ncbi.nlm.nih.gov/26550107Effects of Gum Chewing on Recovery From Postoperative Ileus: A Randomized Clinical Trail.
Ya-Chuan Hsu, Shu-Ying Szu
https://pubmed.ncbi.nlm.nih.gov/35951432Effect of chewing gum on clinical outcomes and postoperative recovery in adult patients after gastrointestinal surgery: an umbrella review.
Shu Ling Lew, Ling Jie Cheng, Siat Yee Yap...
https://pubmed.ncbi.nlm.nih.gov/40072350The Impact of Sham Feeding with Chewing Gum on Postoperative Ileus Following Colorectal Surgery: a Meta-Analysis of Randomised Controlled Trials.
Farah Roslan, Anisa Kushairi, Laura Cappuyns...
https://pubmed.ncbi.nlm.nih.gov/32103455