Actively Recruiting
Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers
Led by Colorado State University · Updated on 2025-12-17
50
Participants Needed
1
Research Sites
274 weeks
Total Duration
On this page
Sponsors
C
Colorado State University
Lead Sponsor
U
University of Colorado, Denver
Collaborating Sponsor
AI-Summary
What this Trial Is About
People who experience repeated bouts of circadian misalignment, such as shift workers, are at higher risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D) compared to daytime workers. However, the mechanism(s) by which shift work and associated circadian misalignment increase CVD and T2D risk are unknown. This project will examine whether elevated plasma lipids are a mechanism by which circadian misalignment impairs vascular function, insulin sensitivity, glucose homeostasis and muscle lipid accumulation, which could be targeted to prevent and treat cardiometabolic disease in people who chronically experience circadian misalignment, which includes more than 20% of the US workforce.
CONDITIONS
Official Title
Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 65 years old
- Worked night shifts for 1 year or more
- Habitual sleep duration of 5 to 9 hours per 24-hour period
- Body mass index (BMI) between 20.0 and 35.0 kg/m2 and weight stable within 5% for the last 6 months
- Sedentary to mild physical activity level (less than 2 days of planned exercise per week)
You will not qualify if you...
- Diagnosed sleep or eating disorders (e.g., obstructive sleep apnea, periodic limb movements of sleep, narcolepsy)
- Travel across more than 1 time zone within 3 weeks before the study
- Anorexia nervosa or more than one food allergy affecting diet flexibility
- Following any time-restricted eating or intermittent fasting plan in the last year
- Following special diet plans like paleo, keto, gluten-free, or vegan in the last 6 months
- Clinically significant surgical condition within the last year
- Diagnosed diabetes or cardiovascular disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Colorado State University
Fort Collins, Colorado, United States, 80523
Actively Recruiting
Research Team
J
Josiane L Broussard, PhD
CONTACT
E
Ellen Lyon, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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