Actively Recruiting
Impact of Cocaine Use and Withdrawal on Sleep
Led by Hôpital le Vinatier · Updated on 2026-04-21
32
Participants Needed
3
Research Sites
145 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates how cocaine use and withdrawal affect sleep and circadian rhythms in individuals undergoing inpatient detoxification. Using wearable sleep monitors, actigraphy, questionnaires, and hormonal biomarkers, it aims to capture both objective and subjective changes in sleep across three key stages: active use, early withdrawal, and late withdrawal. The study is unique in its ability to explore sleep microstructure, the circadian system's role via melatonin and cortisol measurements, and the dynamic relationship between subjective sleep perception and objective sleep data. It also examines whether sleep quality may serve as a predictive marker of long-term withdrawal success.
CONDITIONS
Official Title
Impact of Cocaine Use and Withdrawal on Sleep
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, aged 18 years or older
- Meet DSM-5 criteria for cocaine use disorder
- Have a positive urine drug screen for cocaine
- Scheduled for inpatient supervised cocaine detoxification within the next four weeks
- Covered by a national health insurance plan or social security system
- Have a valid personal contact method (telephone or email) for remote follow-up at 6 months
You will not qualify if you...
- Current diagnosis of opioid use disorder or other psychostimulant use disorders (e.g., amphetamines, methamphetamines, cathinones, methylphenidate)
- Unstable psychiatric disorder or somatic illness that the investigator considers incompatible with study participation
- Current treatment with methylphenidate, modafinil, solriamfetol, melatonin, pitolisant, naltrexone, or bupropion
- Under legal guardianship
- Pregnant or breastfeeding women (pregnancy test required for women of childbearing potential)
- Individuals deprived of liberty by judicial or administrative decision
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Centre Hospitalier Le Vinatier
Bron, AURA, France, 69500
Not Yet Recruiting
2
Centre Hospitalier Le Vinatier
Bron, Auvergne-Rhône-Alpes, France, 69678 cedex
Actively Recruiting
3
CH Le Vinatier
Bron, France, 69500
Actively Recruiting
Research Team
I
ILONA MEDIGUE, PhD student
CONTACT
V
VERONIQUE VIAL, PM
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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