Actively Recruiting
Impact of Depression on Thermoregulation
Led by Penn State University · Updated on 2026-02-03
64
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs and those with depression who are prescribed and taking SNRIs.
CONDITIONS
Official Title
Impact of Depression on Thermoregulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 40 years
- Non-depressed adults aged 18-40 years
- Adults aged 18-40 years with clinically diagnosed major depressive disorder according to DSM-V criteria not currently receiving antidepressant treatment
- Adults aged 18-40 years with major depressive disorder treated for at least 2 weeks with selective serotonin reuptake inhibitors
- Adults aged 18-40 years with major depressive disorder treated for at least 2 weeks with serotonin norepinephrine reuptake inhibitors
- Asymptomatic with no signs or symptoms of disease according to American College of Sports Medicine guidelines
- Systolic blood pressure less than 140 mmHg and diastolic blood pressure less than 90 mmHg at screening
- Non-diabetic
- Not taking medications affecting physiological variables of interest (e.g., beta blockers, tricyclic antidepressants, antipyretics, diuretics)
- Between the 20th and 80th percentiles for sex- and age-appropriate VO2max
- Proficient in English
- Capable of providing informed consent
You will not qualify if you...
- Body mass index (BMI) greater than 35
- Pregnant or planning to become pregnant in the next 12 months
- Currently participating in another study involving physical activity or weight loss
- Planning surgery or relocation outside the area within the next year
- Taking medications that could alter cardiovascular or thermoregulatory responses (e.g., beta blockers, antipyretics, tricyclic antidepressants, diuretics)
- Allergy to latex or adhesive
- Tobacco use
- Illegal or recreational drug use
- Experiencing exertional chest pain or musculoskeletal pain
- Contraindications to maximal exercise test or indications for early test termination per American College of Sports Medicine guidelines
- Abnormal resting or exercise electrocardiogram (ECG)
- Bleeding disorders, gastric ulcers, allergies to NSAIDs, asthma, kidney or liver disorders, or taking other anticoagulants
- History of Crohn's disease, diverticulitis, or similar gastrointestinal diseases
- Co-morbid psychiatric disorders such as psychosis, schizophrenia, bipolar disorder, panic disorder, obsessive-compulsive disorder
- Active moderate or high suicidal ideation
- Use of psychoactive or psychopharmacological drugs other than SSRIs or SNRIs within one year of participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Noll Laboratory
University Park, Pennsylvania, United States, 16802
Actively Recruiting
Research Team
W
W. Larry Kenney
CONTACT
K
Kat G Fisher
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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