Actively Recruiting
Impact of Desflurane Versus Sevoflurane Anesthesia Maintenance on Postoperative Delirium Incidence in Elderly Patients
Led by West China Hospital · Updated on 2024-06-04
890
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Advanced age is a strong risk factor for developing postoperative cognitive decline, which can lead to longer hospital stays, poorer quality of life, and higher mortality. The choice of anesthetic drugs may influence the occurrence of postoperative delirium, but current evidence about this effect is conflicting. This research evaluates how two widely used inhalational anesthetics, desflurane and sevoflurane, affect postoperative delirium and early cognitive dysfunction in elderly patients undergoing surgery. The study compares general anesthesia maintenance with desflurane versus sevoflurane in patients aged 65 to 90 years having non-cardiac and non-neurosurgical procedures lasting two hours or more. Both anesthetics will be administered by inhalation, with doses adjusted to maintain a specific brain activity level measured by the bispectral index between 40 and 60. Pain relief will be provided with remifentanil and sufentanil during surgery, and inhalation of the anesthetics will stop at surgery end. Participants will be monitored for postoperative delirium within seven days after surgery, along with assessments of recovery quality, subjective sleep quality, pain intensity, and cognitive function up to seven days or discharge. Researchers will also track hospital and intensive care unit stay lengths, ICU admissions, and complications within 30 days after surgery. The study uses random assignment and triple masking to compare outcomes between the two anesthetic groups, with total participation lasting through the postoperative observation period.
CONDITIONS
Brief Title
Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older and less than 90 years
- Scheduled for non-cardiac or non-neurosurgery lasting 2 hours or more under general anesthesia
- Agree to participate and provide signed informed consent
You will not qualify if you...
- History of schizophrenia, epilepsy, parkinsonism, or any central nervous system disease before surgery
- Unable to communicate during preoperative period due to coma, dementia, language barrier, impaired hearing, or vision
- Severe cardiovascular, respiratory, liver, or kidney disease, or American Society of Anesthesiologists physical status classification of IV or higher
- Alcoholism or drug dependence
- Any other condition deemed unsuitable for participation by surgeons or investigators (must be documented)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of surgery (2 hours or more)
Participants receive general anesthesia maintained with either desflurane or sevoflurane during surgery. Analgesia is supplemented as needed. Anesthesia is stopped at the end of surgery.
1 visit (in-person, day of surgery)
Duration - Up to 30 days after surgery
Participants are monitored for postoperative delirium, cognitive function, recovery quality, pain intensity, sleep quality, complications, and hospital/ICU stay.
Approximately 1 to 3 visits within 30 days after surgery
Trial Site Locations
Total: 1 location
1
Department of Anesthesiology, West China Hospital
Chengdu, Sichuan, China, 610041
Actively Recruiting
Research Team
J
Jing Yang, MD,PhD
M
Min Xu
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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