Study on How Dialysis Duration and Urine Output Affect Bladder Health in Adults With End-Stage Kidney Disease Waiting for Transplant

What this Trial Is About

This research aims to understand how bladder problems develop in adults with end-stage renal disease ESRD who have been on dialysis for a long time while waiting for a kidney transplant. It focuses on how dialysis duration and the amount of urine produced residual urine output affect bladder capacity and bladder compliance. These bladder changes are important because they can impact the success of kidney transplantation and increase risks like infections and reflux. The study is observational and will assess adult ESRD patients aged 18 to 65 who have been on maintenance dialysis for 6 to 24 months. Participants will undergo clinical assessments, laboratory tests, imaging like ultrasounds, cystoscopy, uroflowmetry, and video-urodynamic studies to evaluate bladder structure and function. Two groups based on urine output levels will be observed to compare bladder conditions. Participants will provide demographic and clinical data, and their bladder function will be evaluated using urodynamic studies to measure bladder capacity, compliance, urinary flow rate, and post-void residual volume. Researchers will analyze these data to find relationships between dialysis duration, urine output, and bladder health. The study aims to identify patients at risk of bladder dysfunction to improve pre-transplant evaluation and post-transplant care, with participation lasting through baseline assessments.

IMPACT OF DIALYSIS DURATION AND DIURESIS ON BLADDER CAPACITY AND COMPLIANCE IN END STAGE RENAL DISEASE PATIENTS AWAITING RENAL TRANSPLANT