Actively Recruiting
Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity
Led by University of Texas Southwestern Medical Center · Updated on 2026-02-17
124
Participants Needed
1
Research Sites
289 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.
CONDITIONS
Official Title
Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults between 18 and 80 years old
- Otherwise healthy without diabetes mellitus
- No chronic kidney disease or preexisting cardiovascular disease
- Not taking any vasoactive agents affecting cardiovascular exercise responses
You will not qualify if you...
- History of cardiopulmonary disease or chronic kidney disease
- Taking antihypertensive medications
- Estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m2
- Diabetes mellitus or other systemic illness
- Pregnancy
- Hypersensitivity to sodium phosphate
- History of substance abuse or current cigarette use
- History of psychiatric illness
- History of active malignancy
- Serum phosphorus less than 2.4 mg/dL or greater than 4.5 mg/dL
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Texas Southwestern
Dallas, Texas, United States, 75209
Actively Recruiting
Research Team
J
John Giacona, PA-C
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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