Actively Recruiting
Impact of a Dried Vegetable on Bowel Function and Gut Microbiota
Led by Wageningen University · Updated on 2025-02-25
160
Participants Needed
1
Research Sites
144 weeks
Total Duration
On this page
Sponsors
W
Wageningen University
Lead Sponsor
W
WholeFiber BV
Collaborating Sponsor
AI-Summary
What this Trial Is About
A randomized, placebo-controlled, parallel, double-blind trial with three intervention arms and a period of four intervention-weeks that assesses the intake of different dosages of a complex fiber product on bowel function via microbiota changes in subjects that are unsatisfied with their current bowel function.
CONDITIONS
Official Title
Impact of a Dried Vegetable on Bowel Function and Gut Microbiota
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged between 20 and 80 years
- Self-reported dissatisfaction with bowel function rated less than 6 on a 0-10 scale
- Four or fewer bowel movements per week and/or hard, lumpy or solid stools during 90% of bowel movements
- Able to read and understand Dutch or English
You will not qualify if you...
- History of medical or surgical conditions affecting bowel function, including IBS, IBD, or medically diagnosed constipation
- Less than one bowel movement per week during screening
- Antibiotic use within 3 months prior to screening
- Chronic use of antacids or proton pump inhibitors
- Use of laxatives during screening
- Chronic use of blood glucose lowering medication
- Use of fiber supplements, pro-/post-/synbiotics within 1 month before screening
- Unwillingness to provide fecal samples or comply with study procedures
- Current or planned pregnancy or lactation for women of childbearing age
- Known allergies to plants in the Asteraceae family (e.g., lettuce, daisies, sunflowers, artichokes, sage, tarragon, chamomile, chicory)
- Unexplained weight change greater than 5 kg in the month before screening
- Following slimming or medically prescribed diets
- Macrobiotic lifestyle
- Employment in the Division of Human Nutrition & Health or the Laboratory of Microbiology
- Current participation in other medical research
- No general practitioner
- Unwillingness to be informed about accidental health discoveries
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Wageningen University & Research, Division of Human Nutrition & Health
Wageningen, Gelderland, Netherlands, 6708 WE
Actively Recruiting
Research Team
E
Edith JM Feskens, Prof. dr
CONTACT
S
Sofie CC van der Zalm, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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