Actively Recruiting
Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest Patients
Led by Hamad Medical Corporation · Updated on 2025-04-03
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a randomized clinical trial to evaluate whether not giving antibiotics to patients who experience out-of-hospital cardiac arrest (OHCA) with a very low chance of infection is as safe as giving early antibiotic treatment. The study aims to compare 28-day all-cause mortality, the incidence of infections, and lengths of ICU and hospital stays between patients receiving early antibiotics and those who do not. The trial is sponsored by Hamad Medical Corporation and focuses on adults admitted to the emergency department after OHCA. Participants with a low risk of infection after OHCA are randomly assigned to one of two groups: one group receives early antibiotic treatment based on hospital protocols and physician choice, while the other group does not receive any antibiotics. The study does not involve masking or blinding, and treatments are delivered according to local clinical care pathways. This approach helps assess the impact of early antibiotic use compared to no antibiotics in this specific patient population. During the study, participants will be monitored for 28 days to track mortality and the occurrence of infections. Researchers will also observe the length of intensive care unit and hospital stays. Consent is obtained from patients or their legal representatives if patients are incapacitated. The trial collects data on patient outcomes to determine if withholding antibiotics is non-inferior to early antibiotic use. The total duration of participation for each patient is at least 28 days post-admission.
CONDITIONS
Brief Title
Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged >18 years presenting to the emergency department after out-of-hospital cardiac arrest
- Patients with low likelihood of infection as defined in the study
- Ability to provide informed consent or have consent given by a legal surrogate or independent physician
You will not qualify if you...
- Patients with clear evidence of infection
- Patients who have received antibiotics within 1 week prior to admission
- Patients with malignancy unless cured or in complete remission
- Females who are pregnant
- Known immunocompromised states including HIV/AIDS, transplant recipients on immunosuppressants, and long-term steroid therapy >3 weeks
- Patients on immunologic disease modifying agents (biologics)
- Patients considered brain-dead or in a vegetative state
- Patients transferred from another hospital or long-term care facility
- Neutropenia with total white blood cell count <1,500/mm3 or absolute neutrophil count <1,000/mm3
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 28 days
Participants are randomized to receive either early antibiotics treatment as per hospital care pathways or no antibiotics after out-of-hospital cardiac arrest.
Visits as per hospital clinical care pathways during treatment period
Duration - Up to 28 days after treatment start
Participants are monitored for outcomes including 28-day all-cause mortality and infection likelihood.
Follow-up visits until day 28
Trial Site Locations
Total: 1 location
1
Hamad Medical Corporation
Doha, Baladiyat ad Dawhah, Qatar
Actively Recruiting
Research Team
A
Adeel A Butt, MBBS, MS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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