Study of Early Antibiotic Use Versus No Antibiotics in Adults After Non-Traumatic Out-of-Hospital Cardiac Arrest

What this Trial Is About

Researchers are conducting a randomized clinical trial to evaluate whether not giving antibiotics to patients who experience out-of-hospital cardiac arrest OHCA with a very low chance of infection is as safe as giving early antibiotic treatment. The study aims to compare 28-day all-cause mortality, the incidence of infections, and lengths of ICU and hospital stays between patients receiving early antibiotics and those who do not. The trial is sponsored by Hamad Medical Corporation and focuses on adults admitted to the emergency department after OHCA. Participants with a low risk of infection after OHCA are randomly assigned to one of two groups one group receives early antibiotic treatment based on hospital protocols and physician choice, while the other group does not receive any antibiotics. The study does not involve masking or blinding, and treatments are delivered according to local clinical care pathways. This approach helps assess the impact of early antibiotic use compared to no antibiotics in this specific patient population. During the study, participants will be monitored for 28 days to track mortality and the occurrence of infections. Researchers will also observe the length of intensive care unit and hospital stays. Consent is obtained from patients or their legal representatives if patients are incapacitated. The trial collects data on patient outcomes to determine if withholding antibiotics is non-inferior to early antibiotic use. The total duration of participation for each patient is at least 28 days post-admission.

Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)