Actively Recruiting
Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)
Led by Hamad Medical Corporation · Updated on 2025-04-03
1000
Participants Needed
1
Research Sites
148 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Specific Aim : The specific aim is to conduct a randomized prospective clinical trial to determine whether no antibiotics in OHCA patients in the ED with very low likelihood of infection is non-inferior to early antibiotic treatment. Hypothesis a: 28-day all-cause mortality will be non-inferior in OHCA patients with very low likelihood of infection who do not receive antibiotic therapy compared with those who receive early antibiotic therapy Hypothesis b: There will be no difference in subsequent incidence of proven infections in the no antibiotics vs, early antibiotics groups Hypothesis c: There will be no difference in the length of ICU stay and overall hospital stay in the early antibiotics vs. no antibiotics groups
CONDITIONS
Official Title
Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged >18 years presenting to the emergency department after out-of-hospital cardiac arrest
- Patients with a low likelihood of infection based on specific definitions
- Ability to provide informed consent or have consent provided by a legal surrogate or independent physician if incapacitated
You will not qualify if you...
- Patients with clear evidence of infection as defined by study criteria
- Patients who have received antibiotics within the past week before admission
- Patients with malignancy unless cured or in complete remission
- Females who are pregnant
- Known immunocompromised individuals, including those with HIV/AIDS, transplant recipients on immunosuppressants, or on long-term steroid therapy (>3 weeks of prednisone >5mg/day equivalent)
- Patients on biologic immunologic disease modifying agents
- Patients considered brain-dead or in a vegetative state
- Patients transferred from another hospital, long-term care facility, or institution
- Patients with neutropenia (total white blood cell count <1,500/mm3 or absolute neutrophil count <1,000/mm3)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hamad Medical Corporation
Doha, Baladiyat ad Dawhah, Qatar
Actively Recruiting
Research Team
A
Adeel A Butt, MBBS, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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