Actively Recruiting
Impact of Early, Personalized Nutritional Management on 1-month Mortality After Acute Stroke
Led by University Hospital, Angers · Updated on 2026-01-08
3084
Participants Needed
12
Research Sites
114 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study evaluate the impact of early personalized nutritional management on 1-month mortality after acute stroke. In the randomised centres of the interventional group (early personalized nutritional management), each patient will be assessed by a dietician within 2 days of stroke. Any swallowing problems are screened, and any barriers to eating are identified before dietary support. Patient's food intakes are recorded until the 7th day post-acute to assess their energy intake. Depending on patient's nutritional objectives, a reinforced feeding strategy comprising 2 levels is put in place, in order to prevent malnutrition: in level 1, the dietician tries to meet nutritional requirements orally, while in level 2 he can recourse to artificial nutrition in the event of failure or inability to meet requirements with oral intake alone. This strategy is started immediately after the initial assessment. Intakes are reassessed every 24 to 48 hours by the dietician in order to adapt the nutritional strategy as quickly as possible in order to cover the patient's personnalized nutritional needs. No change in practice was required of the randomised centres in the control group. All patients will be contacted by telephone 30 days after stroke to collect parts of the assessment criteria, while the other criteria will be collected directly from the patient's computerised medical record. Three months after stroke, an evaluation of quality of life and modified Rankin test will be performed. Our hypothesis is that the implementation of an individualized management of early nutritional support, aimed at compensating for the decrease in intake associated with the disease, would reduce mortality at 30 days in patients hospitalised for stroke.
CONDITIONS
Official Title
Impact of Early, Personalized Nutritional Management on 1-month Mortality After Acute Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
Inclusion Criteria :
- Patients ≥ 18 years of age
- With an acute, ischaemic or haemorrhagic outpatient or inpatient stroke
- NIHSS score ≥ 5
- Hospitalised in a neurology department, or Neuro Vascular Unit (NVU), or in a department where beds are dedicated to receiving post-stroke patients
- Stroke less than 2 days old
- Anticipated length of hospital stay in a participating centre ≥ 5 days
- Patient affiliated to or benefiting from a social security scheme
- Patient or close relative having given written consent to participate in the study or patient included under the emergency procedure in the absence of contactable relatives
Exclusion Criteria:
- Patients treated with nutritional therapy at the time of admission (history of bariatric surgery or gastrectomy, malabsorptive pathologies such as short bowel, extensive intestinal resections, etc.).
- In a palliative situation where life expectancy is < 3 months
- Patient taking part in another study with an impact on mortality or nutrition
- Previous inclusion in the trial
- Pregnant, breast-feeding or parturient woman
- Patient unable to follow the protocol for any reason
- Patient deprived of liberty by judicial or administrative decision
- Patient under compulsory psychiatric care
- Person under legal protection
- Poor understanding of the French language
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
CH Versailles
Chesnay, Yvelines, France, 78150
Actively Recruiting
2
CHU Angers
Angers, France, 49933
Actively Recruiting
3
CHU Caen
Caen, France, 14033
Actively Recruiting
4
CH Cholet
Cholet, France, 49300
Actively Recruiting
5
CHD La Roche sur Yon
La Roche-sur-Yon, France, 85925
Not Yet Recruiting
6
CH La Rochelle
La Rochelle, France, 17000
Actively Recruiting
7
CH Chartres
Le Coudray, France, 28630
Actively Recruiting
8
CHU Rouen
Rouen, France, 76000
Actively Recruiting
9
CHU Nantes
Saint-Herblain, France, 44800
Not Yet Recruiting
10
CH St Malo
St-Malo, France, 35043
Actively Recruiting
11
CHU Toulouse
Toulouse, France, 31059
Not Yet Recruiting
12
CHU Tours
Tours, France, 37000
Not Yet Recruiting
Research Team
A
Angélique CAMPION
CONTACT
A
Anthéa LOIEZ
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here