Functional echocardiography: an emerging clinical tool for the neonatologist.
Martin Kluckow, Istvan Seri, Nick Evans
https://pubmed.ncbi.nlm.nih.gov/17236886Actively Recruiting
Age: 2Hours - 28Days
All Genders
Healthy Volunteers
ID06533787
Impact of Echocardiography on Management of Critically Ill Neonates
Led by Sahar Abozkaly Mahmoud · Updated on 2025-06-03
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying critically ill neonates who show signs of hemodynamic instability to understand their outcomes, including mortality and illness severity. The study evaluates how echocardiography (heart ultrasound) can help manage these unstable newborns by tracking the time it takes for them to become stable again. This observational study compares unstable neonates to a control group of stable neonates to assess the impact of echocardiographic assessments. Neonates in the study receive detailed clinical examinations and echocardiographic assessments using a specialized device. Based on echocardiography results, treatments such as dobutamine, volume expansion, hydrocortisone, dopamine, epinephrine, or interventions for patent ductus arteriosus (PDA) may be given according to specific heart function findings. These procedures are repeated regularly, with daily echocardiographic follow-ups to monitor heart function and stability. Participants undergo continuous monitoring including clinical exams and repeated echocardiograms to evaluate heart function parameters like ejection fraction, ductus arteriosus condition, pulmonary hypertension, and cardiac indexes. These assessments occur daily or at set intervals to track progress. The study involves neonates from birth up to 28 days old, with care and data collection continuing until discharge to measure outcomes and safety throughout hospitalization.
CONDITIONS
Brief Title
Impact of Echocardiography on Management of Critically Ill Neonates
Who Can Participate
Age: 2Hours - 28Days
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Neonates aged 0 to 28 days admitted to the NICU with signs of hemodynamic instability or critical illness
- Inclusion regardless of gestational age, weight, gender, or disease type
You will not qualify if you...
- Failure to obtain informed consent
- Presence of congenital heart disease except for PDA, PFO, or small ASD only
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Until discharge from the NICU
Participants are regularly monitored with clinical examinations and echocardiographic assessments to detect signs of hemodynamic instability or shock.
Daily echocardiographic assessments and clinical examinations
Long-term Monitoring
Duration - Up to 5 days after initial echocardiographic assessment
Participants continue to undergo repeated echocardiographic assessments to evaluate cardiac function and manage conditions such as pulmonary hypertension and PDA.
Repeated echocardiographic assessments daily with an additional assessment 5 days after the first
Trial Site Locations
Total: 1 location
1
Sohag University Hospital
Sohag, Egypt
Actively Recruiting
Loading map...
Research Team
S
Sahar Abuzakaly Mahmoud, MBBS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Hemodynamic monitoring in neonates: advances and challenges.
S Soleymani, M Borzage, I Seri
https://pubmed.ncbi.nlm.nih.gov/20877406Clinicians' abilities to estimate cardiac index in ventilated children and infants.
S M Tibby, M Hatherill, M J Marsh...
https://pubmed.ncbi.nlm.nih.gov/9496187Clinical assessment of cardiac performance in infants and children following cardiac surgery.
Jonathan R Egan, Marino Festa, Andrew D Cole...
https://pubmed.ncbi.nlm.nih.gov/15711976Clinical monitoring of systemic hemodynamics in critically ill newborns.
Willem-Pieter de Boode
https://pubmed.ncbi.nlm.nih.gov/20171815Towards rational management of the patent ductus arteriosus: the need for disease staging.
Patrick J McNamara, Arvind Sehgal
https://pubmed.ncbi.nlm.nih.gov/17951547Does point-of-care functional echocardiography enhance cardiovascular care in the NICU?
A Sehgal, P J McNamara
https://pubmed.ncbi.nlm.nih.gov/18633423