Actively Recruiting
Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial
Led by Dana-Farber Cancer Institute · Updated on 2026-03-11
36
Participants Needed
2
Research Sites
282 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is about determining if an aerobic and resistance exercise intervention is feasible in patients diagnosed with acute or chronic GVHD (Graft-Versus-Host Disease) after having an allogeneic stem cell transplant. The names of the study interventions involved in this study are: * Aerobic and resistance exercise (A+R) - Home-based aerobic and resistance exercise program * Attention control (AC) - Home-based stretching program
CONDITIONS
Official Title
Impact of Exercise on the Complications of Corticosteroids in Patients With GVHD: the RESTART Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 18 years old
- Newly diagnosed with acute or chronic GVHD and starting corticosteroids at 0.20 mg/kg or greater for the first time since transplant
- Received allogeneic stem cell transplant at Dana-Farber Cancer Institute
- Physician's clearance to participate in moderate to vigorous exercise
- Speak English
- Currently participate in less than 60 minutes of structured exercise per week
- Willing to travel to Dana-Farber Cancer Institute for necessary data collection
- Able to understand and willing to sign informed consent
You will not qualify if you...
- Plan for hospital admission within the next 13 weeks at recruitment
- Not enrolled within 14 days after initial steroid treatment
- Pre-existing musculoskeletal or cardiorespiratory conditions
- Uncontrolled illness including active infection, uncontrolled diabetes, hypertension, or thyroid disease
- Receiving other investigational agents or concurrent biological, chemotherapy, or radiation therapy
- Other active malignancies
- Participate in more than 60 minutes of structured exercise per week
- Unable to travel to Dana-Farber Cancer Institute for data collection
- Unable to comply with study safety monitoring requirements
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
2
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
C
Christina Dieli-Conwright, PhD, MPH
CONTACT
J
Jordan Lane, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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