Actively Recruiting
Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study
Led by Bispebjerg Hospital · Updated on 2025-02-21
100
Participants Needed
2
Research Sites
184 weeks
Total Duration
On this page
Sponsors
B
Bispebjerg Hospital
Lead Sponsor
U
University of Copenhagen
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary microvascular function. Hypotheses: The first hypothesis is that in INOCA, with reduced function of microvasculature of the heart, this reduced function also occurs in other organs of the body. The second hypothesis is that regular physical activity (aerobic exercise training) can improve coronary microvascular function, reduce symptoms, and that there is a parallel improvement in vascular function in other organs of the body.
CONDITIONS
Official Title
Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Coronary microvascular dysfunction defined as myocardial blood flow reserve (MBFR) less than 2.5 or hyperemic myocardial blood flow (hMBF) less than 2.3 ml/g/min using [15O]H2O-PET
- No obstructive coronary artery disease
- Age 50 years or older
You will not qualify if you...
- Female patients of childbearing potential (premenopausal females capable of becoming pregnant); female patients must be postmenopausal for at least 1 year or surgically sterile
- Heart failure with left ventricular ejection fraction less than 40%
- Uncontrolled hypertension with blood pressure above 140/90
- Co-morbid conditions with expected survival less than 1 year
- Considered unsuitable for the study by the investigator for any reason
- Unable or unwilling to exercise due to conditions like arthritis or injury
- Already regularly physically active or have a maximal oxygen uptake above 45 ml/kg/min
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57, Frederiksberg, Denmark, 2000
Copenhagen, Denmark, 2400
Not Yet Recruiting
2
Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57
Frederiksberg, Denmark, 2000
Actively Recruiting
Research Team
E
Eva Prescott, MD, DMSc
CONTACT
M
Mads Fischer, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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