Actively Recruiting
The Impact of Exercise on the Tumor Microenvironment in Patients With Lung Cancer
Led by University of Arizona · Updated on 2026-04-21
48
Participants Needed
1
Research Sites
209 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There is increased interest and knowledge about the lung cancer tumor microenvironment (TME). Investigators hypothesize that patients with better baseline physiologic health will have better post-operative outcomes and that strenuous exercise will alter the TME and genetic make-up of the tumor, improving the tumor immune response. Investigators aim to identify the peri-operative and clinical outcomes that differ based on pre-operative VO2max, HRV and resting heart rate following resection of early-stage lung cancer. The physiologic states that are individual and measurable with wearable devices include but are not limited to VO2max, heart rate variability (HRV), and average resting heart rate. Investgators hypothesize that a patient's pre-operative physiologic function with higher VO2max, HRV and lower resting heart rate will be associated with improved peri-operative and post-operative outcomes. Second, investigators will compare alterations in TME based on targeted pre-operative exercise (60-80% of their VO2 max for 75min/week x2 weeks) compared to normal activity adults following resection of early-stage lung cancer. Investigators hypothesize that strenuous exercise in the pre-operative period will impact the TME by increasing levels of cytokines.
CONDITIONS
Official Title
The Impact of Exercise on the Tumor Microenvironment in Patients With Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of lung cancer
- Low risk for submaximal exercise testing based on American Heart Association and American College of Sports Medicine guidelines
You will not qualify if you...
- Younger than 18 years of age
- Requirement for physician approval before exercise indicated on the ACSM-AHA screening questionnaire
- Body mass index greater than 30 kg/m2
- Waist measurement over 102 cm for men or over 88 cm for women
- Chronic or debilitating arthritis
- Bedridden in the past three months
- Common illness within the past six weeks
- HIV infection
- Hepatitis
- History of stroke
- Major affective disorder
- Autoimmune disease
- Pregnant or breastfeeding
- History of severe allergic reaction to an allergen
- Presence of more than one cardiovascular disease risk factor including family history of early myocardial infarction, coronary revascularization, or sudden death in close relatives
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Arizona Cancer Center
Tucson, Arizona, United States, 85719
Actively Recruiting
Research Team
S
Stephanie Worrell, MD
CONTACT
M
Melissa Landau
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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