Actively Recruiting
Impact of Exogenous Ketones on Breathing in Healthy Volunteers
Led by Johns Hopkins University · Updated on 2026-03-31
20
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Exogenous ketones (EK) are compounds that can increase the level of ketones in the body without needing to change what an individual eats. Although EK have been researched mainly in relation to energy and exercise, there haven't been many studies focusing specifically on how EKs affect breathing using well-established scientific methods. The investigators believe that EK may help improve breathing, which could be beneficial for situations like high altitudes, sleep apnea, and exercise. To explore how EK might influence breathing, the investigators are conducting a randomized, placebo-controlled crossover study with healthy volunteers.
CONDITIONS
Official Title
Impact of Exogenous Ketones on Breathing in Healthy Volunteers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index (BMI) between 18 and 30 kg/m2
You will not qualify if you...
- No known sleep disorders such as sleep apnea, insomnia, restless leg syndrome, narcolepsy, or idiopathic hypersomnia; a STOP-BANG score of 5 or higher is also excluded if sleep apnea is not diagnosed
- No current daytime respiratory impairments including uncontrolled asthma, uncontrolled COPD, pneumonia, or interstitial lung disease
- No history of chronic kidney disease or type 1 or type 2 diabetes
- No use of supplemental oxygen
- Not currently on a low carbohydrate diet (<130 g carbohydrate/day), ketogenic diet, intermittent fasting, or using exogenous ketones
- Not pregnant or breastfeeding
- No use of medications such as acetazolamide, SGLT2 inhibitors, or daily opioid use
- No history of claustrophobia or panic disorder
- No frequent alcohol intake (more than 1 drink per day on average or more than 10 drinks per week)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
M
Mariah Potocki
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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