Actively Recruiting
The Impact of Fast Antimicrobial Sensitivity Testing Tools on Stewardship Antibiotic and Clinical Outcome (ACT-FAST)
Led by Istituto Clinico Humanitas · Updated on 2026-03-24
400
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
I
Istituto Clinico Humanitas
Lead Sponsor
B
BioMérieux
Collaborating Sponsor
AI-Summary
What this Trial Is About
The ACT-FAST study aims to compare commercially available Rapid Antimicrobial Susceptibility Testing (R-AST) tools with the current standard of care for patients with Bloodstream Infections (BSI). The primary objective is to evaluate whether "early targeted" antibiotic prescriptions, guided by these rapid tests, can improve antimicrobial stewardship and patient clinical outcomes. To facilitate the evaluation of various diagnostic tools-including those currently on the market and those emerging in the near future-this study utilizes an adaptive clinical trial platform. This flexible design allows for the continuous assessment of different R-AST technologies within a single master protocol, ensuring that the most effective diagnostic strategies are identified efficiently.
CONDITIONS
Official Title
The Impact of Fast Antimicrobial Sensitivity Testing Tools on Stewardship Antibiotic and Clinical Outcome (ACT-FAST)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients admitted to emergency department or hospitalized for any cause in participating hospitals with clinically suspected BSI and positive blood culture.
- At least 18 years of age.
You will not qualify if you...
- Have previously taken part in this trial.
- Concurrently participating in the active phase of a study considered incompatible.
- Patient with severe or terminal disease with life expectancy shorter than 48 h.
- Have an existing directive to withhold life-sustaining treatment, in relation to antibiotic use.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Infectious Disease Unit - IRCCS Humanitas Research Hospital
Rozzano, Milan, Italy, 20089
Actively Recruiting
Research Team
M
Michele Bartoletti, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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