Actively Recruiting
Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity (RANSPRE)
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2026-03-27
14500
Participants Needed
22
Research Sites
204 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
I
INSERM, Epopé team
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine whether first-trimester screening for preeclampsia based on the FMF algorithm (a combination of maternal clinical, sonographic and biochemical parameters), improves maternal or perinatal health.
CONDITIONS
Official Title
Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity (RANSPRE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnancy between 11 and 14 weeks of gestation
- Age 18 years or older
- Affiliated to or beneficiary of a health insurance system (including AME)
- Signed informed consent
You will not qualify if you...
- Gestational age less than 11 weeks or more than 14 weeks
- Known ectopic pregnancy
- Known non-ongoing pregnancy
- Known multiple pregnancy
- History of preeclampsia in a previous pregnancy
- Pregnancies with major fetal abnormality identified at first-trimester ultrasound before randomization
- Absence of health insurance
- Contraindication to aspirin (bleeding disorders, active peptic ulceration, hypersensitivity to aspirin, NSAID-exacerbated respiratory disease, severe liver or heart dysfunction)
- Women regularly taking low-dose aspirin started before pregnancy (except for assisted reproduction indication)
- Age less than 18 years
- Poor understanding of the French language
AI-Screening
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Trial Site Locations
Total: 22 locations
1
CHU Angers
Angers, France
Actively Recruiting
2
CHU de Bordeaux
Bordeaux, France
Actively Recruiting
3
Hôpital Femme Mère Enfant
Bron, France
Actively Recruiting
4
Hôpital Antoine Béclère
Clamart, France
Actively Recruiting
5
CHU Estaing
Clermont-Ferrand, France
Actively Recruiting
6
Hôpital Intercommunal Créteil
Créteil, France
Actively Recruiting
7
CHU Dijon Bourgogne
Dijon, France
Actively Recruiting
8
CHU Lille
Lille, France
Actively Recruiting
9
Hôpital de la conception et de la Timone
Marseille, France
Actively Recruiting
10
Hôpital Nord
Marseille, France
Actively Recruiting
11
CHRU de Nancy
Nancy, France
Actively Recruiting
12
Hôpital Femme - Maternité
Nantes, France
Actively Recruiting
13
Hôpital Armand Trousseau
Paris, France
Actively Recruiting
14
Hôpital Cochin (site Port-Royal)
Paris, France
Actively Recruiting
15
Hôpital Saint-Joseph
Paris, France
Actively Recruiting
16
CHI de Poissy
Poissy, France
Actively Recruiting
17
Hôpital Sud Rennes
Rennes, France
Actively Recruiting
18
CHU Charles Nicolle
Rouen, France
Actively Recruiting
19
CHU Strasbourg, CMCO Schiltigheim
Strasbourg, France
Actively Recruiting
20
Hôpital de Hautepierre
Strasbourg, France
Actively Recruiting
21
Hôpital Paule de Viguier
Toulouse, France
Actively Recruiting
22
Hôpital Bretonneau
Tours, France
Actively Recruiting
Research Team
V
Vassilis TSATSARIS, MD, PhD
CONTACT
V
Valérie PLENCE, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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