Impact of Forced Diuresis Using Furosemide Injection After Flexible Ureteroscopy for Kidney Stone Destruction With Laser: A Randomized Controlled Multicenter Trial with Blinded Evaluation

What this Trial Is About

Flexible ureteroscopy is a common technique used to treat kidney stones by breaking them into small fragments with a laser for removal or natural expulsion. However, some tiny fragments may remain in the kidney after the procedure, potentially leading to new stone formation. Researchers are studying whether forced diuresis, achieved by injecting Furosemide combined with intravenous hydration, can help clear these residual fragments more effectively. This approach has shown positive results in other kidney stone treatments but has not yet been specifically studied with flexible ureteroscopy. Participants in this study will be randomly assigned to receive either an injection of 40 mg of Furosemide over 10 minutes right after the flexible ureteroscopy procedure or usual care without the injection. The trial is designed as a randomized controlled study with blinding of the evaluation. The aim is to determine if this forced diuresis method improves the clearance of stone fragments from the kidney. During the study, researchers will monitor the rate of patients who are stone-free at three months after treatment as the primary outcome. Secondary outcomes include rates of urinary infection within 30 days, pain levels and opioid use during hospital stay, and the number of participants experiencing any adverse events up to three months. Participants will be followed closely during the hospital stay and for three months after their procedure to assess these outcomes and ensure safety.

Impact of Forced Diuresis on the Residual Fragment Rate After Flexible Ureteroscopy for Destruction of Kidney Stones With Laser