Effects of a Natural Nutritional Supplement and Functional Exercise on Mental, Cognitive, and Physical Health in Perimenopausal Women

What this Trial Is About

Researchers are investigating whether a natural-origin nutritional supplement combined with a supervised functional exercise program can improve mood, sleep quality, menopausal symptoms, cognitive function, physical abilities, and neuroendocrine health in perimenopausal women. The study also aims to assess the safety of this combined intervention. This randomized, double-blind, placebo-controlled trial focuses on women aged 45 to 65 years who are in menopausal transition or postmenopause with moderate menopausal symptoms. Participants will be randomly assigned to one of two groups one group will receive a daily natural-origin nutritional supplement along with supervised functional exercise sessions three times per week, while the other group will receive a placebo supplement combined with the same exercise program. The exercise sessions last 45 to 60 minutes and include joint mobility, postural control, functional strength using elastic bands, and coordination exercises. The intervention period lasts 10 weeks. During the study, participants will complete pre- and post-intervention assessments including questionnaires on sleep, mood, well-being, and menopausal symptoms cognitive tests measuring attention, memory, and executive functions physical fitness tests such as strength and gait speed and blood tests for neuroendocrine biomarkers like cortisol, BDNF, IL-6, TNF-alpha, GABA, and serotonin. Adherence to the supplement and exercise program is monitored daily throughout the 10 weeks. The study evaluates changes in these measures to determine effects and safety of the combined intervention.

Impact of Funcional Exercise and Supplementation in Perimenopausal Women's Health