Actively Recruiting
Impact of Genetic Polymorphisms And DASH Diet On Weight Loss Progression In Climacteric Women With Metabolic Syndrome
Led by Nutrindo Ideais Research Center · Updated on 2025-05-18
30
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
N
Nutrindo Ideais Research Center
Lead Sponsor
U
Universidade Federal do Rio de Janeiro
Collaborating Sponsor
AI-Summary
What this Trial Is About
Metabolic syndrome is a multifactorial inflammatory condition that is very prevalent in overweight women with type 2 diabetes. However, there seems to be great benefit in changing lifestyle and dietary patterns in the treatment of this condition. Currently, few studies have shown the effect of a Dietary Approach to Stop Hypertension (DASH) diet in postmenopausal women with metabolic syndrome and the influence of genetic polymorphisms of the fat mass and obesity-associated protein (FTO) and beta-2 adrenergic receptor (ADRB2) genes on inflammatory markers and improvement of laboratory indicators in these patients. This study aims to analyze the interaction of polymorphisms in the ADRB2 and FTO genes and the DASH diet on anthropometric indicators and laboratory tests in patients with metabolic syndrome in the city of Rio de Janeiro. For this purpose, laboratory tests and anthropometric data will be collected in a prospective study with women aged between 40 and 60 years.
CONDITIONS
Official Title
Impact of Genetic Polymorphisms And DASH Diet On Weight Loss Progression In Climacteric Women With Metabolic Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 40 to 60 years
- Obese with BMI greater than 30
- Diagnosed with metabolic syndrome
- Have at least 3 of the following 5 criteria for metabolic syndrome:
- Waist circumference of 89 cm or greater
- Systolic blood pressure 120 mm Hg or higher, or diastolic blood pressure 80 mm Hg or higher, or diagnosed hypertension
- Fasting blood glucose 100 mg/dL or higher, or diagnosed type 2 diabetes
- HDL cholesterol less than 50 mg/dL
- Triglycerides 150 mg/dL or higher
You will not qualify if you...
- Body mass index less than 25 kg/m2
- Active cancer
- Active tuberculosis
- Psychiatric illnesses
- Multiple sclerosis
- Severe nephropathy
- Advanced stages of Paget's disease
- Incomplete participation or poor adherence to the study protocol
- Any complication interfering with study results
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Nutrindo Ideais Research Center
Rio de Janeiro, Brazil, 22421-000
Actively Recruiting
Research Team
G
Guilherme Renke, MD MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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