Actively Recruiting
The Impact of Glomerular Disorders on Bone Quality and Strength
Led by Columbia University · Updated on 2024-07-01
270
Participants Needed
2
Research Sites
285 weeks
Total Duration
On this page
Sponsors
C
Columbia University
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objectives of this study are to: (1) determine the impact of glomerular disease on bone strength and (2) investigate the pathophysiologic underpinnings of impaired bone strength in glomerular disease.
CONDITIONS
Official Title
The Impact of Glomerular Disorders on Bone Quality and Strength
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is enrolled in or eligible for the CureGN study with a diagnosis of glomerulonephropathy
- Age between 5 and 55 years (women must be premenopausal)
- Female participants must have a negative urine or serum pregnancy test
- Stable doses of nutritional vitamin D or active vitamin D therapy for at least 3 months prior to enrollment (if applicable)
- Provide informed consent or parental/guardian permission and child assent as appropriate
You will not qualify if you...
- Currently on chronic dialysis
- History of solid organ transplantation
- Lower extremity amputations or unable to walk
- Active cancer requiring chemotherapy or cancer that has spread to bones
- Diagnosed metabolic bone diseases such as Paget's disease or primary hyperparathyroidism
- Current endocrine disorders like hyperthyroidism, untreated hypothyroidism, or Cushing's syndrome
- Serious medical conditions including end stage liver disease, heart or lung disease, or intestinal malabsorption
- Treatment with bisphosphonates, teriparatide, calcitonin, selective estrogen receptor modulators, estrogen, or phenytoin within the past 12 months
- Previous bilateral fractures of the wrist or tibia
- Pregnant or lactating females
- Participants or guardians who may not comply with study schedules or procedures as judged by the investigator
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
2
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
M
Maria A. Aponte
CONTACT
T
Thomas L. Nickolas, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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