Actively Recruiting
The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality
Led by The Cleveland Clinic · Updated on 2025-12-04
132
Participants Needed
3
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn how GLP-1 and GIP agonists effect bowel preparation in patients scheduled for colonoscopies. The main questions it aims to answer are: * Does GLP-1 and GIP agonist increase the rate of inadequate bowel preparation? * Does the quality of bowel preparation differ in patients who hold vs. those who continue a single dose of their GLP-1 or GIP agonist medication? * Are there any differences in the rates of complications gastric aspiration in patients who hold vs. continue a single dose of their GLP-1 or GIP agonist medication?
CONDITIONS
Official Title
The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient (Age 18 years or older)
- Patient scheduled for outpatient screening, surveillance, or diagnostic colonoscopy
- Using a GLP-1 or GIP agonist at a stable dose for at least one month
You will not qualify if you...
- Unable to provide informed consent, e.g., dementia
- Patient refuses the USMSTF recommended bowel cleansing regimen for patients with diabetes or obesity (split-dose 4 liters polyethylene glycol + 15 mg bisacodyl the afternoon before; low residue diet 3 days before colonoscopy; clear liquid diet the day before colonoscopy)
- Risk factors for inadequate bowel preparation besides diabetes and obesity with a likelihood ratio of 1.6 or greater:
- Cirrhosis
- Parkinson's disease
- Dementia
- Tricyclic antidepressant use
- Opioid use
- Gastroparesis or suspected gastric outlet obstruction on pre-procedure imaging (defined by documented 4-hour solid phase gastric emptying study or prior history of retained gastric contents during upper endoscopy)
- Previous colorectal surgery
- Prior history of inadequate bowel preparation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Cleveland Clinic
Cleveland, Florida, United States, 44195
Actively Recruiting
2
Cleveland Clinic
Cleveland, Florida, United States, 44195
Actively Recruiting
3
Cleveland Clinic Weston
Weston, Florida, United States, 33331
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here