Actively Recruiting
Impact of Guided Biofilm Therapy on Epithelial and Mesenchymal Biomarkers in Periodontitis Patients
Led by University of Baghdad · Updated on 2026-02-27
18
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the clinical and biochemical effects of the guided biofilm therapy protocol as an alternative to the conventional non-surgical periodontal therapy in patients with periodontitis. The main question it aims to answer is: Does the guided biofilm therapy (GBT) protocol have an impact on gingival crevicular fluid (GCF) epithelial and mesenchymal biomarkers in patients with periodontitis? All patients will be instructed to brush their teeth twice daily and will be supplied with the same type of toothpaste and toothbrush, with suitable interdental aids. All patients will be instructed to attend again after 7 days. At baseline, full-mouth periodontal charting and radiographs will be obtained and after 1-hour, GCF samples will be collected from both test and control groups. Sites allocated to control group will undergo supragingival debridement by using ultrasonic device. After one week, the control group will receive RSD using area specific (Gracey) curettes (Medesy, Italy) according to the 24-hours protocol and will receive teeth polishing by using rubber polishing cups and tooth polishing paste, while the test group will receive a full GBT protocol which includes eight steps: (1) ASSESS, (2) DISCLOSE, (3) MOTIVATE, (4) AIRFLOW, (5) PERIOFLOW, (6) PIEZON PS\*, (7) CHECK, and (8) RECALL. After finishing the treatment session, the patients will be asked to attend for follow up, clinical evaluation of PI, BOP, PPD, and CAL, and GCF samples collection after 1 month and 3 months.
CONDITIONS
Official Title
Impact of Guided Biofilm Therapy on Epithelial and Mesenchymal Biomarkers in Periodontitis Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults older than 18 years
- Not currently receiving active periodontal therapy or enrolled in another trial in the last 3 months
- Diagnosed with generalized unstable periodontitis with symmetrical pockets 4mm or deeper and positive bleeding on probing
You will not qualify if you...
- Not diagnosed with periodontitis
- Currently taking antibiotics
- Regular users of nonsteroidal anti-inflammatory drugs (NSAIDs)
- Received periodontal treatment within 3 months prior to the study
- Pregnant or breastfeeding
- Presence of third molars or teeth with furcation involvement
- Taking antioxidant supplements
- Heavy dental calculus preventing sample collection
- History of pulmonary diseases or allergy to erythritol
- Unwilling to participate
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
College of Dentistry, University of Baghdad
Baghdad, Iraq, 10047
Actively Recruiting
Research Team
I
Ibrahim Haider Sadeq, B.D.S
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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