Actively Recruiting
Impact of Highly Effective Modulator Therapy on the Cystic Fibrosis Microbiome
Led by Dartmouth-Hitchcock Medical Center · Updated on 2025-12-16
30
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about the effects of a specific cystic fibrosis therapy (Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapy) on chronic sinonasal disease. The main questions it aims to answer are: 1. How does this therapy impact bacterial communities in the paranasal sinuses? 2. How does this therapy impact inflammation in the paranasal sinuses and olfactory cleft? 3. How does this therapy impact sense of smell and sinonasal disease burden in individuals with cystic fibrosis? 4. How does this therapy impact disease-specific and general quality of life of individuals with cystic fibrosis? Participants will be asked to provide samples from their nose, complete testing of their sense of smell, and complete surveys about their quality of life and sense of smell in this study. Researchers will compare study results between patients who are currently undergoing Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapy and patients who are not currently undergoing therapy.
CONDITIONS
Official Title
Impact of Highly Effective Modulator Therapy on the Cystic Fibrosis Microbiome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects between the ages of 18 years old (inclusive) and 99 years old (inclusive)
- English-speaking
- Diagnosed with CF as established by genetic testing combined with clinical assessment and/or sweat chloride
- Patients being seen at the New Hampshire Cystic Fibrosis Center
- Adults able to sign informed consent
You will not qualify if you...
- Adults unable to consent
- Individuals who are not yet adults
- Prisoners
AI-Screening
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Trial Site Locations
Total: 1 location
1
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
Research Team
R
Ryan E Little, MD
CONTACT
M
Michaela M Geffert, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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