Actively Recruiting
Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation
Led by Vrinnevi Hospital · Updated on 2024-09-19
182
Participants Needed
2
Research Sites
121 weeks
Total Duration
On this page
Sponsors
V
Vrinnevi Hospital
Lead Sponsor
R
Ryhov County Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Because of the high recurrence rates following electrical cardioversion and high morbidity in AF patients there is a need to explore prediction models for AF recurrence following ECV. Previous studies have primarily focused on high-sensitivity CRP (hsCRP), CRP, and IL-6, while other inflammatory indexes and gene scores might hold greater value. This prospective cohort study is planning to include 182 patients with persistent atrial fibrillation, planned for electrical cardioversion, and \>18 years at two medium-sized hospitals in Sweden. Blood samples will be collected prior to electrical cardioversion and at 7-, 30-, 90-, and 180-days follow-up. Atrial fibrillation recurrence will be evaluated at follow-up or upon patient request and diagnosed with 12-lead ECG. An interim analysis will be conducted after more than 80 patients have been included. If the results from univariate and/or multivariable logistic regression on inflammatory markers and genetic expression regarding atrial fibrillation recurrence are significant, the study will be concluded.
CONDITIONS
Official Title
Impact of Inflammatory Indexes and Gene Scores in Prediction of Atrial Fibrillation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Persistent atrial fibrillation (ICD-10 I48.1)
- Age over 18 years
You will not qualify if you...
- Autoimmune disease
- Inflammatory diseases
- Acute or chronic liver dysfunction
- Ongoing infectious diseases
- Thyroid disorders
- Any other conditions known to impact inflammatory activity, including medication use and hematological diseases
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Medical department
Jönköping, Småland, Sweden
Actively Recruiting
2
Cardiology Clinic
Norrköping, Östergötland County, Sweden
Actively Recruiting
Research Team
J
Jakob Hytting, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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