Actively Recruiting
Impact of Infusion Line Change Frequency on Infectious Complications Related to Central Venous Catheters in the Intensive Care Unit ICU
Led by University Hospital, Angers · Updated on 2026-05-13
2830
Participants Needed
27
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In intensive care units, patients often need central venous catheters for care and safe medication delivery, but these devices can lead to infections. Most prevention focuses on how catheters are inserted and handled, but the length of time the catheter stays in place is a main source of infection. This research compares changing infusion sets every 7 days versus every 4 days to see if less frequent changes increase infection risk while considering impacts on nursing workload and costs. The study involves two groups: one where infusion sets connected to the catheter are replaced every 7 days, and another where they are replaced every 4 days, the current standard recommendation. Each replacement involves disconnecting old sets and replacing them with new sterile ones. Both procedures are performed by qualified nurses during the patient's ICU stay. Participants are adult ICU patients with a central venous catheter placed less than 72 hours ago and expected to remain for at least 7 days. Researchers will monitor infections related to the catheter from insertion until 48 hours after removal, along with bloodstream infections, catheter colonization, ICU length of stay, mortality, nursing time, and replacement costs. The study follows patients up to 90 days to collect these outcomes and assess the effects of the different replacement schedules.
CONDITIONS
Brief Title
Impact of Infusion Line Change Frequency on Infectious Complications Related to Central Venous Catheters in the ICU - A Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient
- Any ICU patient with a central venous catheter (inserted by venipuncture) in place for less than 72 hours
- Expected catheter dwell time of at least 7 days
- Patient affiliated with or covered by a social security system
- Patient who has given verbal consent or written consent from a third party or if unable to give consent
You will not qualify if you...
- Documented bloodstream infection at the time of inclusion
- Central venous catheter in place for more than 72 hours
- Suspected catheter-related infection
- Catheter inserted using a guidewire exchange
- Previously enrolled in the study during the same ICU stay
- Condition preventing safe catheter placement, such as allergy to catheter material, confirmed deep vein thrombosis, or skin disorder at insertion site
- Admitted for extensive burns
- Inadequate understanding of the French language
- Pregnant, breastfeeding, or postpartum woman
- Person deprived of liberty by judicial or administrative decision
- Person receiving involuntary psychiatric care
- Person under legal guardianship or other legal protection measure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 90 days or until catheter removal or ICU discharge
Participants receive infusion set replacements connected to their central venous catheter either every 7 days or every 4 days according to their assigned group.
Infusion set replacements every 4 or 7 days during ICU stay
Trial Site Locations
Total: 27 locations
1
La Réunion University Hospital
Saint-Pierre, La Réunion, France, BP350 97448
Not Yet Recruiting
2
Albi Hospital
Albi, France, 81000
Not Yet Recruiting
3
Angers University Hospital
Angers, France, 49933
Actively Recruiting
4
Belfort Hospital
Belfort, France, 90015
Not Yet Recruiting
5
Bourges Hospital
Bourges, France, 18000
Not Yet Recruiting
6
Caen University Hospital
Caen, France, 14033
Not Yet Recruiting
7
CH Carcassonne
Carcassonne, France, 11000
Not Yet Recruiting
8
Chartres Hospital
Chartres, France
Not Yet Recruiting
9
Cholet Hospital
Cholet, France, 49300
Not Yet Recruiting
10
Colombes Hospital
Colombes, France, 92700
Not Yet Recruiting
11
Corbeil-Essonnes Hospital
Corbeil-Essonnes, France, 91106
Not Yet Recruiting
12
AP-HP - Henri Mondor Hospital
Créteil, France, 94000
Not Yet Recruiting
13
Dijon University Hospital
Dijon, France, 21079
Not Yet Recruiting
14
Garches Hospital
Garches, France
Not Yet Recruiting
15
CH Le Mans
Le Mans, France, 72000
Not Yet Recruiting
16
Le Puy en Velay Hospital
Le Puy-en-Velay, France, 43000
Not Yet Recruiting
17
Macon Hospital
Mâcon, France, 71000
Not Yet Recruiting
18
Nantes University Hospital
Nantes, France, 44093
Not Yet Recruiting
19
Orleans University Hospital
Orléans, France, 45067
Not Yet Recruiting
20
AP-HP - Tenon Hospital
Paris, France, 75020
Not Yet Recruiting
21
AP-HP - Saint Louis
Paris, France, 75475
Not Yet Recruiting
22
Pontoise Hospital
Pontoise, France, 95300
Not Yet Recruiting
23
CHU Rennes - service MIR
Rennes, France, 35033
Not Yet Recruiting
24
CHU Rennes - service Réa chir
Rennes, France, 35033
Not Yet Recruiting
25
CH Saint-Nazaire
Saint-Nazaire, France, 44606
Not Yet Recruiting
26
Strasbourg University Hospital
Strasbourg, France, 67091
Not Yet Recruiting
27
CHU Tours
Tours, France, 37000
Not Yet Recruiting
Research Team
C
Carole Haubertin
A
Aurélie Hautefort
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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