Experiences of individuals with acquired brain injury and their families interacting with community services: a systematic scoping review.
Alyson Norman, Valentina Curro, Mark Holloway...
https://pubmed.ncbi.nlm.nih.gov/35244507Actively Recruiting
Phase Not Applicable
Age: 25Years - 65Years
All Genders
ID06130735
Computerized Cognitive Training: Factors Predicting Cognitive Improvement in Acquired Brain Injury Using Intensive 6-Month Training
Led by Brigham and Women's Hospital · Updated on 2025-11-05
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
B
Brigham and Women's Hospital
Lead Sponsor
F
Fujifilm
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating factors that predict cognitive improvement in adults with acquired brain injury or mild cognitive disorders through an intensive computerized cognitive training program. This study focuses on how working memory training affects brain plasticity by measuring changes in cognitive test performance, brain-derived neurotrophic factor (BDNF) levels in blood and saliva, event-related potentials (ERP), and brain imaging techniques such as resting state and structural MRI. The goal is to better understand how intensive cognitive training can influence brain function in this population. Participants will engage in a 6-month training program using the ABI Wellness BEARS platform and the Brainex Software Symbol Relations Module. Training occurs five days a week (Monday to Friday) for 45 to 60 minutes each session. Every two weeks, participants will meet with a facilitator via Zoom to discuss training progress and address any issues. This structured approach aims to provide consistent cognitive challenges and support throughout the study. During the study, participants will attend four in-person assessment visits at Brigham and Women's Hospital and provide blood and saliva samples twice. Researchers will collect data on cognitive performance, BDNF levels, ERP changes, brain imaging results, and self-reported measures including exercise habits, quality of life, sleep, anxiety, depression, fatigue, and thoughts about cognitive skills. The study lasts 12 months, including all assessments and training, to monitor cognitive enhancement and brain changes over time.
CONDITIONS
Brief Title
Impact of Intensive Computerized Cognitive Training
Who Can Participate
Age: 25Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patient of the Mass General Brigham Health System with attention and executive functioning difficulties or diagnosis of mild cognitive disorder or mild neurocognitive disorder due to acquired brain injury sustained at least 12 months ago
- Age between 25 and 65 years
- Proficient in English
- Willing and able to complete all study-related activities for 12 months, including travel for four in-person visits and two sample collections
- Access to a computer with webcam and stable internet
- Have a reliable informant to complete questionnaires about cognition and daily functioning at four time points
You will not qualify if you...
- History of alcohol or substance abuse or dependence within the past 2 years
- High likelihood of a progressive neurodegenerative disorder
- Moderate to severe cognitive disorder indicated by Mini-Mental Status Examination score of 21 or less
- Patient Health Questionnaire (PHQ)-9 score 19 or higher unless deemed not to have active depression
- Active psychotic symptoms
- Severe sensory losses preventing participation in training
- Communication difficulties interfering with participation
- Current participation in another pharmacological or interventional research trial
- Life expectancy less than 2 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
4 in-person visits and 2 sample collection visits
Outpatient Treatment
Duration - 6 months
Participants engage in intensive computerized cognitive training using the ABI Wellness Platform five days per week, with biweekly meetings via Zoom to review progress and address questions.
Training sessions 5 days per week and Zoom meetings every other week
Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
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Research Team
G
George-Ryan Ghorayeb, MA
K
Kayla M Riera, BS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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