Impact of Fluid Infusion Rates During Surgery on Blood Dilution and Small Blood Vessel Function A Prospective Observational Pilot Study

What this Trial Is About

Researchers are investigating the impact of different rates of intraoperative fluid therapy IFT on microcirculation and hemodilution during elective recumbent and laparoscopic surgeries. IFT is used to optimize oxygen delivery to tissues during surgery, but the optimal fluid dosage remains unclear. Surgery can damage the endothelial glycocalyx EG, a key structure affecting microcirculation and tissue metabolism, leading to plasma release and hemodilution. This study aims to understand how IFT affects microcirculation parameters and postoperative outcomes. The study compares several infusion rates of crystalloid solutions based on the type of surgery. For recumbent and laparoscopic surgeries, different infusion rates are given during the first 20 minutes followed by a reduced rate thereafter. The study includes experimental groups with 10%, 20%, and 30% hemodilution, as well as a standard care group. The fluid infusion is tailored by weight mlkgh and administered during surgery to observe its effects. Participants will undergo their planned surgery with assigned fluid infusion rates. Researchers will measure sublingual microcirculation profiles one hour after fluid administration as the primary outcome. The study monitors blood loss and hemodynamic stability during surgery. Participation involves elective surgery and fluid management with no masking or randomization. The trial started in October 2022 and is expected to end in December 2025.

The Impact of Intra-operative Fluid Infusion Rate on Microcirculation