Study on Effects of Blood Pressure Instability During Heart Surgery on Post-Surgery Complications

What this Trial Is About

This research aims to evaluate the impact of intraoperative hemodynamic instability during elective cardiac surgery on major postoperative complications. The study focuses on adult patients undergoing surgeries like coronary artery bypass grafting CABG, valve replacement or repair, or combined procedures using cardiopulmonary bypass. It investigates how low mean arterial pressure MAP < 65 mmHg or the need for vasopressors during surgery relates to outcomes such as delirium, acute kidney injury, stroke, or mortality. Participants are grouped based on whether they experience significant hemodynamic instability during surgery, defined as MAP below 65 mmHg for more than 5 minutes or requiring vasopressor support, versus those with stable intraoperative blood pressure. No interventions are assigned since this is a prospective observational study. The study collects detailed intraoperative data including MAP, heart rate, and vasopressor use, and follows patients for 30 days post-operation to assess adverse outcomes. During the study, participants undergo cardiac surgery with monitoring of their hemodynamics. Researchers assess major postoperative adverse events up to 30 days after surgery, including delirium using CAM-ICU, acute kidney injury per KDIGO criteria, stroke, and mortality. Secondary measures include duration of mechanical ventilation and lengths of ICU and hospital stay. The study is designed to provide evidence on blood pressure management thresholds to improve surgical outcomes, with a total follow-up period of 30 days after the operation.

Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery