Actively Recruiting
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
Led by Frederic T Billings IV · Updated on 2026-04-07
54000
Participants Needed
4
Research Sites
121 weeks
Total Duration
On this page
Sponsors
F
Frederic T Billings IV
Lead Sponsor
M
Multicenter Perioperative Outcomes Group
Collaborating Sponsor
AI-Summary
What this Trial Is About
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes.
CONDITIONS
Official Title
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient located in a participating operating room
- Planned surgery includes tracheal intubation
You will not qualify if you...
- Patient is known to be less than 18 years old
- Patient is known to be pregnant
- Patient is known to be a prisoner
- Patient has American Society of Anesthesiologists (ASA) classification-6 (organ donor)
- Planned surgery includes open heart surgery requiring sternotomy or thoracotomy
- Planned procedure requires prolonged apnea, bronchoscopy, airway surgery, or one-lung ventilation
- Planned surgical case includes use of extracorporeal membrane oxygenation (ECMO)
- Patient has a history of bleomycin treatment
- Patient was enrolled in the trial in the prior 30 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
University of Michigan Hospital
Ann Arbor, Michigan, United States, 48109
Not Yet Recruiting
2
Nebraska Medical Center
Omaha, Nebraska, United States, 68105
Not Yet Recruiting
3
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212
Actively Recruiting
4
University of Utah Huntsman Cancer Institute
Salt Lake City, Utah, United States, 84112
Not Yet Recruiting
Research Team
T
Tracie Baker, CCRA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
3
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