Developmental origins of health and disease--global public health implications.
M A Hanson, P D Gluckman
https://pubmed.ncbi.nlm.nih.gov/25225058Actively Recruiting
Age: 6Months - 6Years
All Genders
ID06662045
Study on the Association Between Iron Deficiency Anemia and Neurobehavioral Development and Cognitive Function in Children Aged 6 to 24 Months
Led by Pingshan District Maternal & Child Healthcare Hospital of Shenzhen · Updated on 2024-10-28
1000
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how iron-deficiency anemia affects neurobehavioral development and cognitive function in children aged 6 to 24 months. This observational study focuses on understanding the impact of anemia on motor skills, language ability, social behavior, and growth measures like weight, height, and body mass index (BMI). The study compares children with iron-deficiency anemia to those without anemia to provide evidence for early interventions supporting healthy development. Participants are grouped into those diagnosed with iron-deficiency anemia and those without anemia. They will undergo blood tests measuring hemoglobin, serum ferritin, and serum iron levels to assess anemia status. Neurobehavioral development will be evaluated using a specialized scale for children aged 0 to 6 years. General health information, including birth history and feeding methods, will be collected through interviews. Throughout the study, children will have baseline assessments and follow-ups at 3 and 6 months for blood tests and developmental evaluations. Researchers will measure neurobehavioral scores, physical growth parameters, and eating behaviors. The study aims to track changes over time to understand anemia's influence on children's growth and development, with parental consent and cooperation essential for participation.
CONDITIONS
Brief Title
Impact of Iron Deficiency Anemia on Neurobehavioral and Cognitive Development in Children Aged 6 to 24 Months
Who Can Participate
Age: 6Months - 6Years
All Genders
Eligibility Criteria
You may qualify if you...
- Children aged 6 to 24 months at the time of enrollment
- Diagnosed with iron-deficiency anemia for the exposure group or confirmed non-anemic status for the control group based on blood test results
- Resident in the study area for at least 6 months prior to enrollment
- Availability of parental or guardian consent to participate and willingness to follow study protocols
- Completion of all baseline assessments including neurodevelopmental and physical growth evaluations
You will not qualify if you...
- Presence of congenital or chronic illnesses affecting neurodevelopment such as Down syndrome or cerebral palsy
- History of severe infections or trauma within 3 months prior to enrollment that could influence neurodevelopment
- Current use of medications or treatments interfering with iron metabolism (e.g., iron supplements or blood transfusions in the last 6 months)
- Premature birth before 37 weeks of gestation or low birth weight under 2,500 grams
- Parental refusal to provide consent or non-compliance with study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo baseline assessments including blood tests for hemoglobin and serum ferritin, neurobehavioral development, physical growth measurements, and eating behavior evaluation.
1 visit (in-person)
Long-term Monitoring
Duration - 6 months
Participants are followed up to monitor neurobehavioral development and physical growth over 6 months, with blood samples collected at 3 months.
Follow-up visits at 3 months and 6 months (in-person)
Trial Site Locations
Total: 1 location
1
Shenzhen Pingshan District Maternity & Child Healthcare Hospital, Department of Child Healthcare
Shenzhen, China/Guangdong, China, 518118
Actively Recruiting
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Research Team
M
Moujinsong Project Manager, M.Sc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Michael K Georgieff
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Ugo Nnenna Chikani, Adaobi Bisi-Onyemaechi, Ijeoma Ohuche...
https://pubmed.ncbi.nlm.nih.gov/34271599Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children.
Lyudmila Pivina, Yuliya Semenova, Monica Daniela Doşa...
https://pubmed.ncbi.nlm.nih.gov/30778834Association of Anemia with Neurodevelopmental Disorders in a Nationally Representative Sample of US Children.
Wenhan Yang, Buyun Liu, Rui Gao...
https://pubmed.ncbi.nlm.nih.gov/33035572Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data.
Gretchen A Stevens, Mariel M Finucane, Luz Maria De-Regil...
https://pubmed.ncbi.nlm.nih.gov/25103581