Study of Iron Overload Effects on Liver Health in Adults Over 10 Years After Allogeneic Stem Cell Transplantation

What this Trial Is About

Researchers are investigating whether chronic iron overload affects the chances of liver problems in adults who are at least 10 years past receiving an allogeneic hematopoietic stem cell transplant allo HSCT. The study will focus on about 400 to 500 survivors who had transplants at Hpital Saint Louis between 2004 and 2014. It aims to understand the impact of iron overload on liver complications, describe the types and frequency of these complications, identify risk factors, and assess long-term effects of prior iron reduction treatments like phlebotomy or chelation. Participants will be evaluated once during their routine annual follow-up visit. The study involves collecting information from medical records about transplant details, previous treatments for iron overload, and past liver events. At the same time, blood tests and non-invasive liver stiffness measurements using FibroScan or shear wave elastography will be performed to assess liver health. During the study visit, researchers will gather lab results and perform liver assessments to monitor liver stiffness and related complications. They will track event-free survival and overall survival regarding liver issues for up to 24 months. The study will help clarify whether monitoring and treating iron overload in long-term allo HSCT survivors can help prevent late liver problems. Participation involves one visit, and all data will be collected during this time.

Impact of Iron Overload on the Incidence of Liver Complications in Long-Term Survivors (≥10 Years) of Allogeneic Hematopoietic Stem-Cell Transplantation.