Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders: a Single-arm Prospective Observational Study

What this Trial Is About

This research investigates how intravenous (IV) iron replacement affects patients with inherited bleeding disorders who also have iron deficiency, defined by low ferritin levels below 50 ng/dL. People with bleeding disorders are more likely to experience iron deficiency and anemia, which can impact platelet production and function, potentially worsening bleeding symptoms. The study aims to better understand this relationship by evaluating bleeding severity and platelet function before and after iron treatment. Participants will receive standard-of-care IV iron therapy in this prospective, single-center observational study. Before treatment, baseline bleeding assessments, quality-of-life questionnaires, and laboratory tests will be conducted. After the IV iron replacement, participants will return for follow-up blood work and questionnaires about three months later to measure any changes. During the study, participants will complete bleeding assessment scores such as ISTH-BAT, menstrual blood loss scores, and epistaxis severity scores before and three months after treatment. Quality of life, fatigue, physical functioning, emotional well-being, and pain will also be assessed using standardized questionnaires. Blood samples will help analyze platelet function changes. This study helps clarify how iron replacement might influence bleeding symptoms and platelet activity in this patient group.

Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders