Actively Recruiting
Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders
Led by Nicoletta C Machin · Updated on 2025-10-03
40
Participants Needed
1
Research Sites
112 weeks
Total Duration
On this page
Sponsors
N
Nicoletta C Machin
Lead Sponsor
H
Health Resources and Services Administration (HRSA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a prospective, single-arm, single-center observational study evaluating the impact of intravenous (IV) iron replacement in patients with inherited bleeding disorders and iron deficiency (ferritin \<50ng/dL). Subjects will undergo baseline bleeding assessments, quality-of-life measures, and laboratory tests before receiving standard-of-care IV iron. Follow-up blood work and questionnaires will be conducted post-replacement to assess for changes
CONDITIONS
Official Title
Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged over 15 years
- Diagnosed with an inherited bleeding disorder such as Von Willebrand disease, platelet disorders, factor deficiencies, or bleeding disorder of unknown cause
- Ferritin level less than 50 ng/mL indicating iron deficiency
- Receiving intravenous iron treatment at the Hemophilia Center of Western Pennsylvania
- Willing to have blood drawn
- Willing to return for a clinic visit 3 months after iron infusion for final assessments
You will not qualify if you...
- History of thrombosis or venous thromboembolism (VTE)
- Platelet count below 100,000 x 10^9/L
- Taking antiplatelet drugs, anticoagulants, aspirin, or NSAIDs concurrently
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hemophilia Center of Western Pennsylvania
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
Research Team
N
Nicoletta Machin, DO
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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