Evaluating Free Gingival Graft Effects on Peri-implant Mucositis Treatment Compared to Non-surgical Therapy Alone

What this Trial Is About

Researchers are investigating how the width of keratinized mucosa affects peri-implant tissues in people with peri-implant mucositis. The study aims to determine if increasing this mucosa width using a free gingival graft FGG alongside non-surgical therapy offers clinical and biochemical benefits compared to non-surgical therapy alone. The key question is whether FGG improves clinical periodontal parameters and inflammatory markers in peri-implant crevicular fluid. The study includes four groups a healthy group with sufficient keratinized mucosa 2mm, a mucositis group with sufficient mucosa, a mucositis group with insufficient mucosa < 2mm receiving only non-surgical treatment, and a mucositis group with insufficient mucosa receiving both FGG and non-surgical treatment. Non-surgical therapy involves oral hygiene instructions, scaling, and subgingival cleaning in a single appointment. For those receiving FGG, the graft is taken from the palate and stitched onto the implant site after preparing the tissue. Participants will be evaluated at baseline, 1 month, 4 months, and 7 months. Researchers will collect peri-implant crevicular fluid samples and measure clinical parameters such as plaque index, gingival index, bleeding on probing, mucosa width, and probing depth at these times. Levels of inflammatory markers IL-1, RANKL, OPG, and their ratio will be analyzed. The study monitors changes in tissue health and inflammation to assess the potential benefits of FGG with non-surgical therapy.

Impact of Keratinized Mucosa Augmentation on Treatment Outcomes of Peri-implant Mucositis