Actively Recruiting
Impact of Keratinized Mucosa Augmentation on Treatment Outcomes of Peri-implant Mucositis
Led by Biruni University · Updated on 2026-02-10
48
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to observe the effects of keratinized mucosa width on peri-implant tissues by evaluating clinical and biochemical parameters. The main question it aims to answer is: Would increasing the width of the keratinized mucosa with free gingival graft (FGG) in peri-implant mucositis be beneficial in terms of clinical periodontal parameters and peri-implant crevicular fluid levels of inflammatory cytokines compared to non-surgical therapy alone? Our study consists of 4 groups: Peri-implant healthy group with sufficient keratinized mucosa (≥ 2mm) (n=16), peri-implant mucositis group with sufficient keratinized mucosa (n=16), peri-implant mucositis group with insufficient keratinized mucosa (\< 2mm) receiving only non-surgical treatment (n=16), peri-implant mucositis group with insufficient keratinized mucosa receiving FGG in addition to non-surgical treatment (n=16). Clinical and biochemical measurements will be recorded at the baseline, 1st month, 4th month and 7th month of the study. Peri-implant crevicular fluid samples will be collected at baseline, 1st month, 4th month and 7th month. IL-1β, RANKL, OPG levels, and RANKL/OPG ratio will be analyzed from collected samples. Researchers will evaluate the possible benefits of FGG application in addition to non-surgical therapy by comparing the biochemical and clinical changes in areas with and without FGG application in the treatment of peri-implant mucositis.
CONDITIONS
Official Title
Impact of Keratinized Mucosa Augmentation on Treatment Outcomes of Peri-implant Mucositis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individual dental implants with fixed prosthetic restorations that have been functional for at least 1 year
- No systemic disease or medication use affecting periodontal or peri-implant tissues
- No periodontal treatment received in the last 6 months
- Volunteering to participate in the study
You will not qualify if you...
- Prosthetic restorations with excessive contour preventing peri-implant pocket measurement
- Being pregnant or breastfeeding
- Having autoimmune or inflammatory diseases of the oral cavity
- Active periodontal disease
- Smoking 10 or more cigarettes per day
- Having improperly positioned implants
AI-Screening
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Trial Site Locations
Total: 1 location
1
Biruni University
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
A
Ayse E Selman
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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