How Kidney Failure Affects Immune Response to Influenza Vaccination Observational Study Comparing Dialysis Patients and Healthy Individuals

What this Trial Is About

This research aims to understand how kidney failure influences the bodys immune response to vaccination, specifically focusing on patients who require chronic dialysis. Researchers will compare how well the flu vaccine triggers protective antibodies in patients undergoing hemodialysis or peritoneal dialysis against those without chronic kidney disease. The study is observational and seeks to clarify the impact of kidney failure on vaccine effectiveness. Participants will receive a single dose of the influenza vaccine and may also be evaluated for a single dose of the SARS-CoV-2 vaccine. The study includes three groups patients on thrice-weekly hemodialysis, patients on peritoneal dialysis, and healthy individuals without kidney disease. There is no treatment assignment since it is an observational study, and participants are enrolled at the time of their influenza vaccination. After vaccination, participants will visit the clinic at 7, 14, 30, 60, and 120 days to provide clinical information and blood samples. Researchers will measure antibody responses and immune cell activity over time, focusing mainly on the frequency of serological response within 30 days and other immune markers up to 120 days. The total participation duration spans about four months, including safety and immune response monitoring.

Impact Of Kidney Failure On The Regulation Of Humoral Response To Vaccination