Actively Recruiting
Impact Of Kidney Failure On The Regulation Of Humoral Response To Vaccination
Led by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Updated on 2026-03-30
146
Participants Needed
3
Research Sites
89 weeks
Total Duration
On this page
Sponsors
F
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Lead Sponsor
F
Fondazione Cariplo
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis. Researchers will compare the effectiveness of the influenza vaccine in inducing protective antibodies between hemodialysis patients and subjects without chronic kidney disease. Participants will: * Be enrolled at the time of influenza vaccination * Visit the clinic at 7, 14, 30, 60, and 120 days after vaccination * Be asked to provide relevant clinical information and a blood sample at each visit
CONDITIONS
Official Title
Impact Of Kidney Failure On The Regulation Of Humoral Response To Vaccination
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years
- Patients undergoing thrice-weekly hemodialysis or peritoneal dialysis for at least 3 months OR healthy individuals without a history of renal insufficiency
- Eligible to receive a seasonal influenza vaccine
- Signed informed consent for participation in the study
You will not qualify if you...
- Recent influenza infection clinically resolved less than 3 months ago
- Use of immunosuppressive drugs in the two weeks before vaccination
- Received another vaccine in the three weeks before enrollment (except co-administration with study vaccines)
- Systemic infection clinically resolved less than two weeks before enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Italy, 20122
Actively Recruiting
2
ASST Santi Paolo e Carlo
Milan, Italy, 20142
Not Yet Recruiting
3
ASST Fatebenefratelli Sacco
Milan, Italy, 20157
Not Yet Recruiting
Research Team
M
Manuel A Podesta', MD, PhD
CONTACT
G
Giuseppe Castellano, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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