Actively Recruiting
Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease
Led by Khyber Medical University Peshawar · Updated on 2025-12-19
45
Participants Needed
2
Research Sites
36 weeks
Total Duration
On this page
Sponsors
K
Khyber Medical University Peshawar
Lead Sponsor
N
Northwest General Hospital and Research centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.
CONDITIONS
Official Title
Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 42 years
- Diagnosed with fatty liver (NAFLD) via imaging (e.g., ultrasound)
- Liver fibrosis assessed and staged via FibroScan and the FIB-4 index
- Literate to consent and complete cognitive assessments/questionnaires
You will not qualify if you...
- History of alcohol intake greater than 20 grams per day
- Chronic viral hepatitis B or C
- Major neuropsychiatric illnesses
- Pregnancy or breastfeeding
- Chronic illnesses including Diabetes Mellitus and thyroid dysfunction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Khyber Teaching Hospital
Peshawar, KPK, Pakistan, 25100
Actively Recruiting
2
Northwest General Hospital
Peshawar, KPK, Pakistan, 25100
Actively Recruiting
Research Team
D
Dr Ayesha Qaiser, MBBS, PhD Scholar
CONTACT
D
Dr Inayat Shah, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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