Actively Recruiting
Impact of Long-term Dutasteride Use on Perioperative Outcomes of HoLEP
Led by Ankara City Hospital Bilkent · Updated on 2026-04-06
1000
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the effects of long-term dutasteride use (a 5-alpha reductase inhibitor) on surgical outcomes in patients undergoing Holmium Laser Enucleation of the Prostate (HoLEP) for benign prostatic hyperplasia (BPH). While some studies suggest that short-term use of these medications can reduce bleeding during surgery, there is limited data on the impact of chronic, long-term use (at least 6 months) specifically during the HoLEP procedure. The researchers will retrospectively analyze patient records to compare two groups: those who used dutasteride for 6 months or longer before surgery, and those who did not use any 5-alpha reductase inhibitors. The primary focus is to determine whether long-term dutasteride treatment leads to a significant difference in surgical bleeding (measured by hemoglobin drop), operation time, and the efficiency of removing prostate tissue (morcellation). The findings will help surgeons better understand how preoperative medication history influences the technical aspects of HoLEP surgery.
CONDITIONS
Official Title
Impact of Long-term Dutasteride Use on Perioperative Outcomes of HoLEP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male patients aged 40 to 80 years
- Diagnosed with symptomatic Benign Prostatic Hyperplasia (BPH) and scheduled for elective Holmium Laser Enucleation of the Prostate (HoLEP)
- For the study group: Continuous use of Dutasteride (0.5 mg/day) for at least 6 months immediately before surgery
- For the control group: No 5-alpha reductase inhibitor use within the last 12 months
- Complete medical records available in the Hospital Information Management System (HBYS)
You will not qualify if you...
- History of previous prostate surgery or pelvic radiotherapy
- Diagnosis of prostate adenocarcinoma in pathology or scheduled biopsy for suspected prostate cancer before surgery
- Incomplete data in hospital records, including missing operative notes, hemoglobin levels, or resected tissue weight
AI-Screening
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Trial Site Locations
Total: 1 location
1
Ankara Bilkent City Hospital
Ankara, Universiteler, Turkey (Türkiye), 06800
Actively Recruiting
Research Team
Y
Yusuf Gökkurt, MD, Specialist
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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