Role of Manual Therapy for Neck Pain and Quality of Life in Head and Neck Cancer Survivors: A Systematic Review.
Renu B Pattanshetty, Sayali Nandkumar Patil
https://pubmed.ncbi.nlm.nih.gov/35673382/Actively Recruiting
Led by Johns Hopkins University · Updated on 2026-06-22
20
Participants Needed
2
Research Sites
N/A
Total Duration
Researchers are studying the effects of voice therapy combined with manual neck treatments on patients who experience swallowing or voice changes after total thyroidectomy. This trial aims to find out if adding neck massage, stretches, and pain neuroscience education to voice exercises and scar massage helps reduce complaints related to swallowing, voice, scar tethering, and overall quality of life after surgery. Participants will be randomly assigned to one of two groups. One group receives manual massage to the anterior neck, neck stretches, pain neuroscience education, voice exercises, and scar massage. The other group receives voice exercises and scar massage along with placebo versions of the manual therapy, stretches, and pain education. The treatment involves five speech-language pathology sessions, including exercises and tests, one before and four after surgery. Throughout the study, participants have four visits with their endocrine or laryngology surgeon for evaluations and endoscopic tests. They also keep a journal of their home exercise practice. Researchers will measure voice clarity and quality, speaking pitch, swallowing quality of life, laryngeal sensation, scar tethering distance, and scar quality at the start and one year after treatment. Adverse effects will also be monitored. The study lasts until December 2027.
CONDITIONS
Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy
C
Claire W Ligon, M.Ed.
V
Vaninder Dhillon, MD
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Johns Hopkins University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Manual Therapy-Based Rehabilitation | Placebo Rehabilitation |
|---|---|---|
| What is this approach? | A rehabilitation program combining anterior neck manual therapy, neck stretches, pain neuroscience education, Stemple voice exercises, and scar massage for patients following total thyroidectomy. | A comparison protocol including Stemple voice exercises and scar massage with placebo manual therapy (very gentle touch) and placebo pain neuroscience education after thyroidectomy. |
| Role in the trial | Designed to test whether combined manual therapy and education improve laryngeal function and quality of life compared to placebo rehabilitation. | Serves as a control arm with standard voice exercises and scar massage, mimicking other rehabilitation components with placebo versions. |
| Primary use and goal | Intended to maximize recovery of laryngeal function, voice quality, swallowing comfort, and scar mobility after thyroidectomy. | Aims to provide minimal rehabilitation focusing on voice exercises, scar massage, and simulated manual therapy and education, as a baseline for comparison. |
| How is it delivered? | Manual massage is applied to the anterior neck muscles, accompanied by bilateral cervical stretches, structured pain neuroscience education, Stemple voice exercises, and digital scar massage. | Participants receive Stemple voice exercises and scar massage, while placebo manual therapy involves light contact, and pain education covers generic post-surgical topics. |
| Evidence status | Manual therapy, stretches, and combined rehabilitation are supported by emerging evidence for neck pain and post-surgical recovery, but robust RCTs in thyroidectomy are limited. | Voice exercises and scar massage have published evidence for improvement in voice quality and scar comfort after thyroidectomy. |
| Important limitations | Evidence for manual therapy in post-thyroidectomy patients is limited to small studies. Effects may differ depending on individual anatomy and surgical outcomes. Long-term efficacy and safety require further validation. | Placebo-controlled approaches—minimal manual contact and generic pain education—may not reflect real-world rehabilitation or capture all relevant patient needs. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
4 visits with endocrine or laryngology surgeon, 1 pre-surgery speech-language pathology session
Duration - Approximately 4 to 5 sessions after surgery
Participants receive either manual neck therapy with stretches, pain education, voice exercises, and scar massage or voice exercises and scar massage with placebo manual therapy and education.
5 speech-language pathology sessions total including 1 before and 4 after surgery
Duration - Up to 1 year after surgery
Participants complete assessments and journaling of home exercise practice to monitor voice and swallowing outcomes up to one year after surgery.
Periodic evaluations including endoscopic tests at 1 year
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Have more questions? Get in touch with our team for quick support
Renu B Pattanshetty, Sayali Nandkumar Patil
https://pubmed.ncbi.nlm.nih.gov/35673382/Galletti Bruno, Sciumè Melissa, Catalano Natalia...
https://pubmed.ncbi.nlm.nih.gov/32654042/Vanessa Veis Ribeiro, Vanessa Pedrosa, Kelly Cristina Alves Silverio...
https://pubmed.ncbi.nlm.nih.gov/28844806/Holly McMillan, Carly E A Barbon, Richard Cardoso...
https://pubmed.ncbi.nlm.nih.gov/35297966/Jae Seok Lee, Jin Pyeong Kim, Jun Sun Ryu...
https://pubmed.ncbi.nlm.nih.gov/30054014/Johns Hopkins University
Lead Sponsor