Actively Recruiting
Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology
Led by University of California, San Francisco · Updated on 2025-07-30
80
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a single-center study of 80 subjects with asthma including those with obesity and metabolic dysfunction (MD), those with obesity and without metabolic dysfunction, those with severe asthma and mucus plugging and those with severe asthma and without mucus plugging. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in a cardiopulmonary exercise testing (CPET) visit to compare lung function markers and change in oxygen saturation between obese patients with and without MD and severe asthma patients with and without mucus plugging.
CONDITIONS
Official Title
Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female 18 years or older at Visit 0
- Written informed consent and ability to follow study requirements
- History of physician-diagnosed asthma
- Evidence of bronchodilator reversibility (12% improvement in FEV1 after albuterol) or positive methacholine challenge
- Meets criteria for obesity (BMI 6 30) or severe asthma requiring high-dose inhaled corticosteroids plus another controller, systemic corticosteroid, or biologic therapy
- For obesity with metabolic dysfunction, defined by either plasma IL-6 > 3.0 pg/mL or insulin resistance (HOMA-IR > 3 mass units)
- For severe asthma, mucus plugging defined by mucus plug score 6 4
You will not qualify if you...
- Asthma exacerbation or upper respiratory infection within the previous 6 weeks
- History of smoking:
- If under 30 years old, smoked for 5 or more pack-years
- If 30 years or older, smoked for 10 or more pack-years
- Pregnancy
- Absolute or relative contraindications to exercise testing according to ATS criteria
- Any other conditions that place the subject at unnecessary risk according to the Principal Investigator or attending physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCSF Airway Clinical Research Center
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
J
Jade Vi, BS
CONTACT
J
John Fahy, MD, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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