Actively Recruiting
Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational Study
Led by Marmara University · Updated on 2026-03-12
59
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore how various metabolic markers, such as HOMA-IR, triglyceride/HDL ratio, HbA1c, and body measurements like waist and hip circumference and BMI, relate to pain and central sensitization in women diagnosed with lipedema. Lipedema is a chronic condition marked by symmetrical fat buildup in the legs, easy bruising, and pain that may not be explained solely by mechanical factors. The study focuses on understanding the connection between metabolic dysfunction and central pain processing, which has been suggested but not extensively studied in lipedema. The study includes female patients aged 18 and older who have been diagnosed with lipedema and have recent laboratory results assessing metabolic markers. This is a cross-sectional observational study without treatment interventions. Participants have their metabolic marker data reviewed and will complete several assessments at baseline to evaluate pain intensity, fatigue, neuropathic pain features, physical function, sleep quality, and activity levels. Participants will be involved in completing a series of questionnaires and scales including the Central Sensitization Inventory, Numeric Rating Scale for pain, Fatigue Severity Scale, Neuropathic Pain Diagnostic Questionnaire, Short Form-12, Jenkins Sleep Scale, Lower Extremity Functional Scale, and International Physical Activity Questionnaire. These assessments help researchers measure the relationship between metabolic factors and pain characteristics. The study is sponsored by Marmara University and is expected to conclude by March 2027.
CONDITIONS
Brief Title
The Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female aged 18 years or older
- Chronic pain lasting at least 3 months
- Ability to understand and respond to study assessments
- Voluntary participation with written informed consent
You will not qualify if you...
- History of malignancy, active infection, inflammatory rheumatic disease, or severe systemic illness
- Known neurological disorders such as stroke, multiple sclerosis, or epilepsy
- Severe psychiatric disorders including psychotic or bipolar disorders
- Pregnancy or breastfeeding
- Cognitive impairment or communication difficulties affecting study participation
- Diagnosed diabetes mellitus
- Active thyroid disease not controlled
- Cushing's syndrome or other major endocrine disorders
- Use of antidiabetic medications
- Use of lipid-lowering drugs like statins or fibrates
- Systemic glucocorticoid use within the past 3 months
- Use of medications affecting central pain mechanisms, such as high-dose opioids or antipsychotics
- Major surgery or invasive pain treatment within the past 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants complete assessments and questionnaires to evaluate metabolic markers, pain intensity, central sensitization, and functional status.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Marmara University Faculty of Medicine Pendik Training and Research Hospital
Istanbul, Pendik, Turkey (Türkiye), 34890
Actively Recruiting
Research Team
F
Fatma B Akdağ
Y
Yeliz Özdemir
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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