Study on How Metabolic Health Affects Pain and Central Sensitization in Women With Lipedema

What this Trial Is About

This research aims to explore how various metabolic markers, such as HOMA-IR, triglycerideHDL ratio, HbA1c, and body measurements like waist and hip circumference and BMI, relate to pain and central sensitization in women diagnosed with lipedema. Lipedema is a chronic condition marked by symmetrical fat buildup in the legs, easy bruising, and pain that may not be explained solely by mechanical factors. The study focuses on understanding the connection between metabolic dysfunction and central pain processing, which has been suggested but not extensively studied in lipedema. The study includes female patients aged 18 and older who have been diagnosed with lipedema and have recent laboratory results assessing metabolic markers. This is a cross-sectional observational study without treatment interventions. Participants have their metabolic marker data reviewed and will complete several assessments at baseline to evaluate pain intensity, fatigue, neuropathic pain features, physical function, sleep quality, and activity levels. Participants will be involved in completing a series of questionnaires and scales including the Central Sensitization Inventory, Numeric Rating Scale for pain, Fatigue Severity Scale, Neuropathic Pain Diagnostic Questionnaire, Short Form-12, Jenkins Sleep Scale, Lower Extremity Functional Scale, and International Physical Activity Questionnaire. These assessments help researchers measure the relationship between metabolic factors and pain characteristics. The study is sponsored by Marmara University and is expected to conclude by March 2027.

The Impact of Metabolic Status on Pain and Central Sensitization in Women With Lipedema: A Cross-Sectional Observational Study