Study of a Lifestyle Program to Reduce Dementia Risk in Adults Aged 65 to 75 with Family History of Dementia

What this Trial Is About

Researchers are studying dementia, which has many causes and limited treatment options, focusing on individuals aged 65 to 75 who are at high risk but do not yet have cognitive impairment. The study aims to assess how people feel about their dementia risk as they receive personalized risk information and to pilot the use of data collection and a lifestyle intervention designed to reduce dementia risk factors. It also seeks to identify key risk contributors and dementia sub-types based on genetics and molecular markers. Participants are divided into two groups based on their risk for cognitive decline using factors like family history, genetics APOE genotype and Alzheimers disease polygenic risk score, cardiovascular risk, lifestyle, cognitive assessment scores, raceethnicity, and pTau217 biomarker levels. Those at high risk will be offered a multimodal lifestyle intervention that includes healthy eating MIND Diet, physical activity, stress and weight management, social and learning activities, and cognitive training through an online program. Health coaching via telephone supports participants, with coaching tailored to each individuals biological and behavioral data. During the study, researchers will track participants attitudes about dementia risk at enrollment, after they learn their risk level, and after completing the intervention if applicable. They will also measure biomarkers like pTau217 and cognitive scores MoCA at several points. The study involves surveys, cognitive assessments, physical tests, and sample collection, with participants needing internet access for some activities. This study runs from May 2025 to April 2026, with ongoing monitoring to evaluate the impact of personalized risk information and lifestyle changes on dementia risk.

Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study