Actively Recruiting
Impact of Native Chicory Inulin on Change and Persistence of Gut Microbiota
Led by Purdue University · Updated on 2025-12-11
52
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main aim of this study is to investigate differences in rate, extent of change and persistence of the gut microbiota in healthy adult volunteers in response to native chicory inulin. Along with investigating the impact of native chicory on bowl habits, mood and appetite. The two main questions this study aims to answer: * To what extent do differences exist in rate of change over time between individuals in gut microbiota response (Bifidobacterium growth) to native chicory inulin supplementation. * To what extent do differences exist between individuals in persistence of the gut microbiota upon stopping supplementation. The effects of native chicory inulin on gut microbiota response will be compared to a maltodextrin placebo to sure changes in gut microbiota result directly from chicory inulin supplementation. Participants will firstly complete a one-week run-in phase to establish baseline data and will then be allocated to either native chicory inulin or maltodextrin supplementation for 6 weeks. Inulin will be delivered at 12 g/day split into 2 x 6g portions. Maltodextrin will be calorie matched at 6 g/day split into 2 x 3g portions. This will then be followed by a 6 week post-supplementation phase. Fecal and blood samples will be collected regularly throughout all phases for analysis of gut microbiota and compounds of interest. Participants will also record any changes in gastrointestinal sensation, bowel habits and mood in a diary. Changes in appetite sensation will also measured.
CONDITIONS
Official Title
Impact of Native Chicory Inulin on Change and Persistence of Gut Microbiota
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 45 years
- Body mass index (BMI) greater than 18.5 and less than 30 kg/m2
- Regular bowel movements more than 4 days per week
You will not qualify if you...
- Sensitivity to FODMAPs or following a low FODMAP diet
- Food allergies or sensitivities including gluten, dairy, nuts, soya, lactose
- Antibiotic treatment within the past 6 months
- History of gastrointestinal disease, heart disease, cardiovascular, liver, respiratory disorders, cancer, or clinically relevant (pre) diabetes
- Major gastrointestinal surgery except gallbladder removal or appendix removal
- Smoking or drug or alcohol abuse
- History of psychiatric or mood disorders including eating disorders
- Following a restrictive diet such as ketogenic or intermittent fasting
- Pregnant or lactating women
AI-Screening
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Trial Site Locations
Total: 1 location
1
Purdue University
West Lafayette, Indiana, United States, 47907
Actively Recruiting
Research Team
S
Stephen Lindemann, PhD
CONTACT
P
Peter Jackson, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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